INT327786

Context Info Confidence 0.29 First Reported 2010 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 3 Total Number 4 Disease Relevance 4.21 Pain Relevance 0.44

transmembrane transporter activity (AQP1) plasma membrane (AQP1) nucleus (AQP1) transmembrane transport (AQP1) cytoplasm (AQP1)

Anatomy Link Frequency astrocytes 2 body 2 endothelial cells 1 AQP1 1 AQP1 (Homo sapiens)

Pain Link Frequency Relevance Heat cerebral cortex 6 99.68 Spinal cord 36 96.40 Peripheral nervous system 5 70.16 Central nervous system 7 65.92 Neuropathic pain 2 61.04 Inflammation 16 48.36 Hippocampus 3 44.84 Pain 2 43.28 Neurotransmitter 7 25.92 potassium channel 10 24.72

Disease Link Frequency Relevance Heat Creutzfeldt Jakob Disease 30 99.08 Lewy Body Disease 9 98.56 Disease 212 98.08 Frailty 2 96.40 Prion Diseases 18 93.76 Brain Tumor 1 93.56 Hypoxia 1 90.32 Cancer 10 78.32 Congenital Anomalies 6 74.72 Pressure And Volume Under Development 8 70.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These observations suggest that astrocyte end-feet may signal adjacent endothelial cells to switch of endothelial AQP1 expression.

Negative_regulation (switch) of in endothelial cells Gene_expression (expression) of AQP1 in AQP1

1) Confidence 0.29 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.69 Pain Relevance 0.30

Significant increased expression levels of AQP1 and AQP4 were seen in CJD, but not in advanced AD and DLB cases.

Negative_regulation (levels) of Gene_expression (levels) of AQP1 associated with creutzfeldt jakob disease, lewy body disease and disease

2) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.49 Pain Relevance 0.05

Furthermore, Rodriguez and colleagues [79] analyzed AQP1 and AQP4 expression in the cerebral cortex of CJD patients compared to that in cases with AD and diffuse Lewy body disease (DLB).

Spec (analyzed) Negative_regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of AQP1 in body associated with creutzfeldt jakob disease, lewy body disease, disease and cerebral cortex

3) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.46 Pain Relevance 0.05

This study also revealed the lack of uniformity of AQP1 expression when comparing astrocytes: some astrocytes were not stained with anti-AQP1 antibodies, whereas AQP1 expression was marked in others.

Negative_regulation (marked) of Gene_expression (expression) of AQP1 in astrocytes

4) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.57 Pain Relevance 0.04

General Comments

This test has worked.