INT327786

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 4.21
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transporter activity (AQP1) plasma membrane (AQP1) nucleus (AQP1)
transmembrane transport (AQP1) cytoplasm (AQP1)
Anatomy Link Frequency
astrocytes 2
body 2
endothelial cells 1
AQP1 1
AQP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cerebral cortex 6 99.68 Very High Very High Very High
Spinal cord 36 96.40 Very High Very High Very High
Peripheral nervous system 5 70.16 Quite High
Central nervous system 7 65.92 Quite High
Neuropathic pain 2 61.04 Quite High
Inflammation 16 48.36 Quite Low
Hippocampus 3 44.84 Quite Low
Pain 2 43.28 Quite Low
Neurotransmitter 7 25.92 Quite Low
potassium channel 10 24.72 Low Low
Disease Link Frequency Relevance Heat
Creutzfeldt Jakob Disease 30 99.08 Very High Very High Very High
Lewy Body Disease 9 98.56 Very High Very High Very High
Disease 212 98.08 Very High Very High Very High
Frailty 2 96.40 Very High Very High Very High
Prion Diseases 18 93.76 High High
Brain Tumor 1 93.56 High High
Hypoxia 1 90.32 High High
Cancer 10 78.32 Quite High
Congenital Anomalies 6 74.72 Quite High
Pressure And Volume Under Development 8 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations suggest that astrocyte end-feet may signal adjacent endothelial cells to switch of endothelial AQP1 expression.
Negative_regulation (switch) of in endothelial cells Gene_expression (expression) of AQP1 in AQP1
1) Confidence 0.29 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.69 Pain Relevance 0.30
Significant increased expression levels of AQP1 and AQP4 were seen in CJD, but not in advanced AD and DLB cases.
Negative_regulation (levels) of Gene_expression (levels) of AQP1 associated with creutzfeldt jakob disease, lewy body disease and disease
2) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.49 Pain Relevance 0.05
Furthermore, Rodriguez and colleagues [79] analyzed AQP1 and AQP4 expression in the cerebral cortex of CJD patients compared to that in cases with AD and diffuse Lewy body disease (DLB).
Spec (analyzed) Negative_regulation (analyzed) of Spec (analyzed) Gene_expression (expression) of AQP1 in body associated with creutzfeldt jakob disease, lewy body disease, disease and cerebral cortex
3) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.46 Pain Relevance 0.05
This study also revealed the lack of uniformity of AQP1 expression when comparing astrocytes: some astrocytes were not stained with anti-AQP1 antibodies, whereas AQP1 expression was marked in others.
Negative_regulation (marked) of Gene_expression (expression) of AQP1 in astrocytes
4) Confidence 0.25 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 0.57 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox