INT327801

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 6
Total Number 9
Disease Relevance 7.67
Pain Relevance 7.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp2) plasma membrane (Aqp2) protein complex (Aqp2)
transmembrane transport (Aqp2) lysosome (Aqp2) cytoplasm (Aqp2)
Anatomy Link Frequency
dorsal root ganglia 6
spinal cord 4
neurons 3
neuronal 2
vessels 2
Aqp2 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 48 99.78 Very High Very High Very High
Sciatic nerve 17 99.70 Very High Very High Very High
Spinal cord 97 99.40 Very High Very High Very High
trigeminal ganglion 36 98.68 Very High Very High Very High
Peripheral nervous system 36 95.76 Very High Very High Very High
Migraine 164 95.16 Very High Very High Very High
Dorsal horn 34 93.84 High High
Pain 123 92.12 High High
Inflammation 21 91.60 High High
IPN 1 90.96 High High
Disease Link Frequency Relevance Heat
Injury 93 99.78 Very High Very High Very High
Inflammatory Pain 13 99.72 Very High Very High Very High
Ganglion Cysts 44 98.68 Very High Very High Very High
Headache 144 95.16 Very High Very High Very High
Neuropathic Pain 64 94.48 High High
Nociception 76 92.84 High High
Pressure And Volume Under Development 35 92.16 High High
Pain 135 92.12 High High
INFLAMMATION 21 91.60 High High
Disease 26 84.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
AQP2 expression increased in the cytoplasm and neuronal membrane of small-sized neurons, while the AQP2 immunostaining decreased in the cytoplasm of medium/large sized neurons with a strong increase in the neuronal membrane.
Positive_regulation (increased) of Gene_expression (expression) of AQP2 in neuronal
1) Confidence 0.44 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.69 Pain Relevance 0.47
CCI treatment induced a significant increase of AQP2 expression restricted to DRG and not in spinal cord.
Positive_regulation (induced) of Gene_expression (expression) of AQP2 in spinal cord associated with eae and spinal cord
2) Confidence 0.44 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.63 Pain Relevance 0.45
Moreover, CCI treatment did not induce AQP2 expression at the CCI injury site but in some small vessels of DRG.
Neg (not) Positive_regulation (induce) of Gene_expression (expression) of AQP2 in vessels associated with eae and injury
3) Confidence 0.30 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.84 Pain Relevance 0.63
CCI treatment induced a significant increase of AQP2 expression restricted to DRG and not in spinal cord.
Positive_regulation (increase) of Gene_expression (expression) of AQP2 in spinal cord associated with eae and spinal cord
4) Confidence 0.30 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923366 Disease Relevance 0.62 Pain Relevance 0.45
Moreover, after chronic constriction of sciatic nerve (CCI) in rat, AQP2 expression increased in small-diameter dorsal root ganglia neurons but also in Schwann cells [13].
Positive_regulation (increased) of Gene_expression (expression) of AQP2 in dorsal root ganglia associated with sciatic nerve
5) Confidence 0.29 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.33 Pain Relevance 0.56
However, AQP-2 expression was dramatically increased in small-diameter dorsal root ganglia neurons in response to chronic constriction injury treatment [56].
Positive_regulation (increased) of Gene_expression (expression) of AQP-2 in dorsal root ganglia associated with eae and injury
6) Confidence 0.19 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.11 Pain Relevance 1.36
The AQP-1 expression remained unaltered in TG in a mice model of perioral acute inflammatory pain although the AQP-2 expression was remarkably increased in small-sized neurons and Schwann cells [56].
Positive_regulation (increased) of Gene_expression (expression) of AQP-2 in neurons associated with eae and trigeminal ganglion
7) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.23 Pain Relevance 0.99
AQP-2 expression was not detectable either in the spinal cord or in the dorsal root ganglia of naive rats.
Neg (not) Positive_regulation (detectable) of Gene_expression (expression) of AQP-2 in dorsal root ganglia associated with spinal cord
8) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.98 Pain Relevance 1.33
The AQP-1 expression remained unaltered in TG in a mice model of perioral acute inflammatory pain although the AQP-2 expression was remarkably increased in small-sized neurons and Schwann cells [56].
Positive_regulation (increased) of in Schwann cells Gene_expression (expression) of AQP-2 in neurons associated with eae and trigeminal ganglion
9) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 1.23 Pain Relevance 0.99

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