INT32781

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Context Info
Confidence 0.47
First Reported 1985
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 7
Total Number 11
Disease Relevance 4.31
Pain Relevance 1.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Vip)
Anatomy Link Frequency
pituitary 2
regulatory T cell 2
skeleton 1
Vip (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 99 99.60 Very High Very High Very High
monoamine 2 99.36 Very High Very High Very High
Inflammation 114 97.28 Very High Very High Very High
Serotonin 2 97.24 Very High Very High Very High
Neurotransmitter 6 93.92 High High
cytokine 204 89.84 High High
Peripheral nervous system 3 87.20 High High
Central nervous system 69 82.88 Quite High
Potency 2 79.04 Quite High
agonist 2 76.64 Quite High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 99 99.60 Very High Very High Very High
Fatigue 33 98.40 Very High Very High Very High
Autoimmune Disease 57 98.28 Very High Very High Very High
Nociception 6 97.32 Very High Very High Very High
INFLAMMATION 147 97.28 Very High Very High Very High
Hypoxia 9 95.76 Very High Very High Very High
Increased Venous Pressure Under Development 6 86.60 High High
Pneumonia 117 82.96 Quite High
Sprains And Strains 108 82.16 Quite High
Bacterial Meningitis 18 78.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We have examined the interactions, in eliciting cAMP accumulation, between vasoactive intestinal polypeptide (VIP) and the three monoamines norepinephrine (NE), histamine (HIS), and serotonin (5-hydroxytryptamine, 5-HT) in mouse cerebral cortical slices.
vasoactive intestinal polypeptide Spec (examined) Binding (interactions) of associated with serotonin and monoamine
1) Confidence 0.47 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2983040 Disease Relevance 0 Pain Relevance 0.34
We have examined the interactions, in eliciting cAMP accumulation, between vasoactive intestinal polypeptide (VIP) and the three monoamines norepinephrine (NE), histamine (HIS), and serotonin (5-hydroxytryptamine, 5-HT) in mouse cerebral cortical slices.
VIP Spec (examined) Binding (interactions) of associated with serotonin and monoamine
2) Confidence 0.46 Published 1985 Journal J. Neurosci. Section Abstract Doc Link 2983040 Disease Relevance 0 Pain Relevance 0.34
The biological effects of VIP are mediated by G protein-coupled receptors (VPAC1 and VPAC2) that bind VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) with equal affinity, and a PACAP selective receptor (PAC1) [25].
VIP Binding (bind) of in pituitary
3) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.40 Pain Relevance 0.19
VIP has also been implicated in the neuro-osteogenic interactions in the skeleton.
VIP Binding (interactions) of in skeleton
4) Confidence 0.32 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.63 Pain Relevance 0.28
Treatment in PACAP/VIP postulated autoimmune neuropsychiatric fatigue-related disorders
VIP Binding (Treatment) of associated with fatigue
5) Confidence 0.28 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.62 Pain Relevance 0.10
They have key roles in blood vessels in the CNS84 and VIP is associated with maintaining functional integrity of the BBB.83 PACAP and VIP influence regulatory T cell (Treg)29 and other immune functions.
VIP Binding (associated) of in regulatory T cell
6) Confidence 0.28 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.66 Pain Relevance 0.23
The biological effects of VIP are mediated by G protein-coupled receptors (VPAC1 and VPAC2) that bind VIP and pituitary adenylate cyclase-activating polypeptide (PACAP) with equal affinity, and a PACAP selective receptor (PAC1) [25].
VIP Binding (bind) of in pituitary
7) Confidence 0.28 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1257432 Disease Relevance 0.47 Pain Relevance 0.22
They have key roles in blood vessels in the CNS84 and VIP is associated with maintaining functional integrity of the BBB.83 PACAP and VIP influence regulatory T cell (Treg)29 and other immune functions.
VIP Binding (integrity) of in regulatory T cell
8) Confidence 0.25 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2695238 Disease Relevance 0.67 Pain Relevance 0.24
Thus, the identification of peptides that bind to multiple HLA types, the so-called “promiscuous” or “universal” epitope(s), could lead to effective coverage of the human population using peptide-based vaccine.
peptides Binding (bind) of
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.05 Pain Relevance 0
This analysis revealed that nearly all PspA peptides could potentially bind a variety of mouse and human MHC class II molecules.
peptides Binding (bind) of
10) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.32 Pain Relevance 0
To identify the immunodominant epitopes of PspA, we used in silico MHC affinity measurement methods using both affinity data from the Immune Epitope Database and Analysis Resource (IEDB) [14], eluted peptide data from the SYFPEITHI [12] database as well as RANKPEP [15], SVMHC [16], and MHCPred tools [17], [18], which predicted the PspA peptides that bind HLA-DR, -DQ, and -DP alleles.
peptides Binding (bind) of
11) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2828482 Disease Relevance 0.47 Pain Relevance 0.04

General Comments

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