INT327817

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Context Info
Confidence 0.17
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.83
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ADORA2A) enzyme binding (ADORA2A) cell-cell signaling (ADORA2A)
signal transducer activity (ADORA2A)
ADORA2A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 10 100.00 Very High Very High Very High
adenocard 24 99.98 Very High Very High Very High
Glutamate 6 70.56 Quite High
Inflammation 22 22.36 Low Low
Bioavailability 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
psoriasis 4 5.00 Very Low Very Low Very Low
Nicotine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 8 97.20 Very High Very High Very High
Amnesia 4 94.88 High High
Convulsion 8 89.84 High High
Dementia 2 84.44 Quite High
Metabolic Syndrome 86 83.36 Quite High
Hypoxia 22 78.40 Quite High
Erectile Dysfunction 2 75.52 Quite High
Sleep Initiation And Maintenance Disorders 4 73.88 Quite High
Sleep Disorders 40 72.84 Quite High
Diabetes Mellitus 16 67.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is of interest that a combination of a phosphodiesterase-5 inhibitor and an adenosine ADORA2A antagonist, mimicking two major mechanisms of action of caffeine, prevented the memory impairment, though neither drug alone had such effect.
Negative_regulation (antagonist) of ADORA2A associated with cognitive disorder, adenocard and antagonist
1) Confidence 0.17 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 1.34 Pain Relevance 0.14
Ever since the influential review by Snyder and Sklar [20], caffeine has been perceived as a “magic” nonselective antagonist of ADORA1 and ADORA2A.
Negative_regulation (antagonist) of ADORA2A associated with antagonist
2) Confidence 0.15 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.49 Pain Relevance 0.14

General Comments

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