INT327818

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.28
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GPRC6A) signal transducer activity (GPRC6A)
GPRC6A (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 5 76.08 Quite High
adenocard 12 67.56 Quite High
addiction 2 50.00 Quite Low
Neurotransmitter 1 37.44 Quite Low
agonist 4 34.88 Quite Low
Inflammation 11 5.00 Very Low Very Low Very Low
cytokine 3 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Kinase C 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 16 98.10 Very High Very High Very High
Toxicity 4 95.16 Very High Very High Very High
Metabolic Syndrome 44 85.56 High High
Sleep Initiation And Maintenance Disorders 2 49.56 Quite Low
Sleep Disorders 20 48.52 Quite Low
Weight Gain 8 45.04 Quite Low
Cancer 20 5.00 Very Low Very Low Very Low
Obesity 16 5.00 Very Low Very Low Very Low
Cardiovascular Disease 13 5.00 Very Low Very Low Very Low
Hypoxia 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(vi) Network analysis of direct interactions and associated tables of network statistics were created with Metacore Version 4.7 (GeneGo, St.
analysis Binding (interactions) of
1) Confidence 0.01 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958630 Disease Relevance 0 Pain Relevance 0
For example, starting drug doses may be tailored to an individual's metabolism, thereby increasing therapeutic efficacy and reducing side effects; individuals for whom a particular drug should be avoided altogether, to avert toxicity or “idiosyncratic” reactions, might be identified by prior genetic screening; and mechanistic insights into the development of particular diseases, drug side effects, or toxicities resulting from environmental exposures might be garnered by analysis of associations with specific genes [1, 2].
analysis Binding (associations) of associated with toxicity and disease
2) Confidence 0.01 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958679 Disease Relevance 0.19 Pain Relevance 0
In order to reduce the complexity of the expected target display, we employed a commercially available engine for drug target identification and recording their interaction, Ingenuity Pathway Analysis (IPA) [23].
Analysis Binding (interaction) of
3) Confidence 0.00 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.09 Pain Relevance 0.13

General Comments

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