INT327821

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Context Info
Confidence 0.00
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.50
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Lep) extracellular region (Lep) intracellular (Lep)
plasma membrane (GPRC6A) lipid metabolic process (Lep) signal transducer activity (GPRC6A)
Anatomy Link Frequency
adipocytes 2
GPRC6A (Homo sapiens)
Lep (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dexamethasone 1 90.80 High High
Inflammation 11 37.28 Quite Low
agonist 2 12.72 Low Low
adenocard 12 5.00 Very Low Very Low Very Low
antagonist 5 5.00 Very Low Very Low Very Low
Glutamate 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 16 100.00 Very High Very High Very High
Syndrome 1 79.84 Quite High
Sleep Initiation And Maintenance Disorders 2 74.56 Quite High
Body Weight 2 65.52 Quite High
Sleep Disorders 20 64.16 Quite High
Metabolic Syndrome 43 58.08 Quite High
INFLAMMATION 11 37.28 Quite Low
Hyperplasia 3 35.04 Quite Low
Injury 2 32.08 Quite Low
Weight Gain 8 14.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In vitro analysis, using isolated rat adipocytes incubated with MEL (1 nM) and INS, did not affect LEP expression when administered alone, whereas administered together they have increased it by 120%.
analysis Neg (not) Regulation (affect) of Gene_expression (expression) of LEP in adipocytes associated with obesity
1) Confidence 0.00 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923369 Disease Relevance 0.50 Pain Relevance 0.05

General Comments

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