INT327824

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Context Info
Confidence 0.67
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 5.40
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
brain 4
glial cells 2
spinal cords 2
astrocytes 2
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 55 98.46 Very High Very High Very High
unmyelinated 3 88.36 High High
Multiple sclerosis 3 86.28 High High
cva 9 85.36 High High
Dorsal horn 22 80.56 Quite High
depression 16 79.80 Quite High
Neuritis 3 77.48 Quite High
Central nervous system 28 70.16 Quite High
painful pain 4 69.60 Quite High
qutenza 12 56.64 Quite High
Disease Link Frequency Relevance Heat
Brain Tumor 12 99.98 Very High Very High Very High
Frailty 24 99.84 Very High Very High Very High
Malignant Neoplastic Disease 9 99.24 Very High Very High Very High
Hemangioblastoma 4 99.20 Very High Very High Very High
Disease 26 97.76 Very High Very High Very High
Brain Injury 7 97.68 Very High Very High Very High
Pressure And Volume Under Development 29 97.04 Very High Very High Very High
Glioblastoma 9 96.56 Very High Very High Very High
Hypoxia 12 95.16 Very High Very High Very High
Cyst 10 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Upregulation of brain AQP-1 expression is found in Alzheimer patients [41], Creutzfeldt-Jakob disease [42], traumatic brain injury patients, and human hemangioblastomas.
Positive_regulation (Upregulation) of Gene_expression (expression) of AQP-1 in brain associated with hemangioblastoma, disease and brain injury
1) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.64 Pain Relevance 0.23
In all cases, the elevated AQP-1 expression seems to occur in astrocytes residing in diseased brain tissue, even though these astrocytes and other glial cells do not normally express AQP-1.
Positive_regulation (elevated) of Gene_expression (expression) of AQP-1 in glial cells
2) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.65 Pain Relevance 0.21
The possible roles of increased expression of AQP-1 in the etiology of different neuropathological conditions are still unknown, but it is likely that AQP-1 up-regulation may contribute to edema and cyst formation-typical outcomes in most of these pathological conditions.
Positive_regulation (increased) of Gene_expression (expression) of AQP-1 associated with pressure and volume under development and cyst
3) Confidence 0.67 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.65 Pain Relevance 0.18
After spinal cord injury (SCI) there was evidence that reactive astrocytes show a significant increase of AQP1 expression surrounding the lesion site, while reactive astrocytes distant from the lesion express markedly less it [58].
Positive_regulation (increase) of Gene_expression (expression) of AQP1 in astrocytes associated with frailty and spinal cord
4) Confidence 0.53 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 1.14 Pain Relevance 0.26
Moreover, in CNS, hypertonicity induces AQP-1 synthesis via extracellular signal-regulated kinases, p38 kinase, and c-Jun terminal kinase [44].
Positive_regulation (induces) of Gene_expression (synthesis) of AQP-1
5) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2974658 Disease Relevance 0.55 Pain Relevance 0.25
Hypoxic conditions may contribute to chronic accumulation of water within neurons and cytotoxic edema that can account for the increased water content in chronically injured spinal cords, given that the antioxidant melatonin significantly decreases AQP1 expression induced by SCI [59].
Positive_regulation (induced) of Gene_expression (expression) of AQP1 in spinal cords associated with pressure and volume under development, hypoxia and frailty
6) Confidence 0.36 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.86 Pain Relevance 0.08
In brain tumours AQP1 expression increases with the grade of malignancy [64, 81].
Positive_regulation (increases) of Gene_expression (expression) of AQP1 in brain associated with malignant neoplastic disease and brain tumor
7) Confidence 0.36 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.90 Pain Relevance 0.17

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