INT327827

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.80
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Aqp1) transmembrane transporter activity (Aqp1) plasma membrane (Aqp1)
nucleus (Aqp1) transmembrane transport (Aqp1) cytoplasm (Aqp1)
Anatomy Link Frequency
spinal cords 2
Aqp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dorsal horn 2 80.96 Quite High
Spinal cord 9 76.52 Quite High
Neuritis 1 44.32 Quite Low
unmyelinated 1 22.88 Low Low
Multiple sclerosis 1 6.08 Low Low
cva 3 5.16 Low Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frailty 8 99.52 Very High Very High Very High
Pressure And Volume Under Development 7 97.24 Very High Very High Very High
Hypoxia 4 95.36 Very High Very High Very High
Injury 5 90.16 High High
Cyst 2 88.64 High High
Neuritis 1 44.32 Quite Low
Cancer 10 40.76 Quite Low
Skin Cancer 1 40.44 Quite Low
Adhesions 1 40.16 Quite Low
Alzheimer's Dementia 1 12.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypoxic conditions may contribute to chronic accumulation of water within neurons and cytotoxic edema that can account for the increased water content in chronically injured spinal cords, given that the antioxidant melatonin significantly decreases AQP1 expression induced by SCI [59].
Negative_regulation (decreases) of Gene_expression (expression) of AQP1 in spinal cords associated with pressure and volume under development, hypoxia and frailty
1) Confidence 0.45 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.80 Pain Relevance 0.08

General Comments

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