INT327830

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.15
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Alms1, Aqp4) transport (Aqp4) cilium (Alms1)
protein complex (Aqp4) transmembrane transport (Aqp4) lipid metabolic process (Alms1)
Anatomy Link Frequency
microglia 1
Alms1 (Mus musculus)
Aqp4 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 8 30.48 Quite Low
Spinal cord 9 5.00 Very Low Very Low Very Low
Peripheral nervous system 8 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Dorsal horn 2 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
hyperexcitability 1 5.00 Very Low Very Low Very Low
IPN 1 5.00 Very Low Very Low Very Low
Multiple sclerosis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cerebral Edema 8 98.30 Very High Very High Very High
Autism 8 55.56 Quite High
Targeted Disruption 6 49.16 Quite Low
Infection 2 36.96 Quite Low
Disease 2 32.44 Quite Low
Cancer 10 5.00 Very Low Very Low Very Low
Frailty 8 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 7 5.00 Very Low Very Low Very Low
Epilepsy 5 5.00 Very Low Very Low Very Low
Glioma 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In fact the intranigral injection of lipopolysaccharide, that mimics the BBB disruption in memingoencephalitis [75] and provokes severe vasogenic brain edema, produced an area of disappearance of astrocytes probably due to the opening of the BBB which filled with reactive microglia expressing AQP4 mRNA and protein.
BBB Positive_regulation (expressing) of AQP4 in microglia associated with cerebral edema
1) Confidence 0.03 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923371 Disease Relevance 0.15 Pain Relevance 0

General Comments

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