INT327858

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Context Info
Confidence 0.45
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.13
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
cleavage 2
Notch1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 32 77.20 Quite High
Apoptosis 1 57.24 Quite High
Myocardial Infarction 1 28.72 Quite Low
Congenital Anomalies 1 21.64 Low Low
Infarction 1 20.44 Low Low
Rupture 1 19.32 Low Low
Adhesions 2 7.04 Low Low
Death 7 5.00 Very Low Very Low Very Low
Infection 2 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was previously reported that Notch1 is first synthesized as a 300-kDa precursor protein and that following the glycosylation step, Notch1 is cleaved by a furin-like convertase (site 1 cleavage; S1 cleavage) to form a heterodimer receptor composed of a 230-kDa extracellular domain (N1EC) and a 120-kDa transmembrane domain (N1™); and then the mature heterodimeric Notch1 is trafficked to the cell surface [17], [18].
Positive_regulation (following) of Protein_catabolism (cleaved) of Notch1 in cleavage
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.13 Pain Relevance 0

General Comments

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