INT327863

Context Info Confidence 0.30 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 1.27 Pain Relevance 0.14

extracellular region (Postn) cell adhesion (Postn) proteinaceous extracellular matrix (Postn) extracellular matrix organization (Postn)

Anatomy Link Frequency Notch 1 Postn (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 16 94.40 cytokine 8 5.00 anesthesia 4 5.00

Disease Link Frequency Relevance Heat Stress 128 98.56 Death 28 96.16 Apoptosis 4 78.60 Myocardial Infarction 4 50.08 Congenital Anomalies 4 43.00 Infarction 4 41.80 Rupture 4 40.68 Adhesions 8 28.40 Sprains And Strains 4 11.96 Infection 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To detect the association of Notch1 and periostin proteins, we performed immunoprecipitation of Notch1 by using anti-FLAG antibody followed by Western blot analysis using anti-periostin antibody, revealing the presence of periostin in the precipitate of Notch1 (Fig. 1B).

periostin Binding (association) of

1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0

Recently, it was proposed that periostin influences Notch signaling by binding to an integrin receptor, which inhibits the expression of Dlk1 (negative regulator of Notch signaling) to enhance Notch signaling [27].

periostin Binding (binding) of in Notch

2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 1.04 Pain Relevance 0.14

Periostin physically associates with Notch1 precursor at its EGF repeats

Periostin Binding (associates) of

3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.23 Pain Relevance 0

However, our results suggest another role for periostin, i.e., association with EGF motifs of the Notch1 precursor inside the cell during membrane trafficking. 120-kDa transmembrane domain of Notch1 (N1™) is decreased in Pn?

periostin Binding (association) of

4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0

General Comments

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