INT327863

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Context Info
Confidence 0.30
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.27
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Postn) cell adhesion (Postn) proteinaceous extracellular matrix (Postn)
extracellular matrix organization (Postn)
Anatomy Link Frequency
Notch 1
Postn (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 16 94.40 High High
cytokine 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 128 98.56 Very High Very High Very High
Death 28 96.16 Very High Very High Very High
Apoptosis 4 78.60 Quite High
Myocardial Infarction 4 50.08 Quite High
Congenital Anomalies 4 43.00 Quite Low
Infarction 4 41.80 Quite Low
Rupture 4 40.68 Quite Low
Adhesions 8 28.40 Quite Low
Sprains And Strains 4 11.96 Low Low
Infection 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To detect the association of Notch1 and periostin proteins, we performed immunoprecipitation of Notch1 by using anti-FLAG antibody followed by Western blot analysis using anti-periostin antibody, revealing the presence of periostin in the precipitate of Notch1 (Fig. 1B).
periostin Binding (association) of
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
Recently, it was proposed that periostin influences Notch signaling by binding to an integrin receptor, which inhibits the expression of Dlk1 (negative regulator of Notch signaling) to enhance Notch signaling [27].
periostin Binding (binding) of in Notch
2) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 1.04 Pain Relevance 0.14
Periostin physically associates with Notch1 precursor at its EGF repeats
Periostin Binding (associates) of
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.23 Pain Relevance 0
However, our results suggest another role for periostin, i.e., association with EGF motifs of the Notch1 precursor inside the cell during membrane trafficking.

120-kDa transmembrane domain of Notch1 (N1™) is decreased in Pn?

periostin Binding (association) of
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0

General Comments

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