INT32787

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Context Info
Confidence 0.38
First Reported 1985
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.37
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Tyr) cell proliferation (Tyr) oxidoreductase activity (Tyr)
cellular_component (Tyr) cytoplasm (Tyr)
Anatomy Link Frequency
blood 2
foot 2
Tyr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Clonidine 7 99.68 Very High Very High Very High
Dopamine 50 99.52 Very High Very High Very High
diclofenac 70 98.70 Very High Very High Very High
Enkephalin 20 92.72 High High
monoamine 3 88.00 High High
Rostral ventrolateral medulla 1 86.04 High High
medulla 2 82.32 Quite High
Opioid 1 48.32 Quite Low
cINOD 5 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Shock 2 98.80 Very High Very High Very High
Hypotension 3 98.28 Very High Very High Very High
Parkinson's Disease 1 17.60 Low Low
Neurological Disease 1 8.00 Low Low
Stress 10 5.00 Very Low Very Low Very Low
Apoptosis 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Avoidance training increased Tyr production, as did handling and exposing animals to the novel avoidance chamber without foot-shock training.
Positive_regulation (increased) of Gene_expression (production) of Tyr in foot associated with shock
1) Confidence 0.38 Published 1993 Journal Peptides Section Abstract Doc Link 8483796 Disease Relevance 0.10 Pain Relevance 0.39
On the other hand, Tyr-Gly-Gly production was elevated by blood sampling alone, by handling/novelty, and by training, but the effect of training was significantly greater than the effects of either of the other treatments.
Positive_regulation (elevated) of Gene_expression (production) of Tyr in blood
2) Confidence 0.38 Published 1993 Journal Peptides Section Abstract Doc Link 8483796 Disease Relevance 0.10 Pain Relevance 0.39
In response to DCF treatment the proportion of DOPAC and DA decreased, whereas the proportion of TAs (OCT, TYR, and PEA) increased.
Positive_regulation (increased) of Gene_expression (proportion) of TYR associated with dopamine and diclofenac
3) Confidence 0.13 Published 2008 Journal Journal of Neurochemistry Section Body Doc Link PMC2324205 Disease Relevance 0 Pain Relevance 0.63
Inhibition of aminopeptidase with bestatin (116 microM) blocked the formation of tyrosine and enhanced production of Tyr-Gly-Gly.
Positive_regulation (enhanced) of Gene_expression (production) of Tyr-Gly
4) Confidence 0.03 Published 1985 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2983067 Disease Relevance 0 Pain Relevance 0.64
Clonidine attenuated the increases in c-fos in the mNTS and cRVLM and c-jun gene expression in the mNTS and rRVLM caused by NP-evoked hypotension and also reduced the basal expression of c-jun mRNA in the mNTS and rRVLM.
Positive_regulation (increases) of Gene_expression (expression) of cRVLM associated with hypotension and clonidine
5) Confidence 0.01 Published 2000 Journal Brain Res. Section Abstract Doc Link 10677633 Disease Relevance 0.18 Pain Relevance 0.72

General Comments

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