INT327871

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Context Info
Confidence 0.38
First Reported 2010
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 11
Disease Relevance 1.42
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) extracellular matrix organization (Postn)
embryo development (Notch1) cytoplasm (Notch1) extracellular region (Postn)
Anatomy Link Frequency
Notch 1
molar 1
Notch1 (Mus musculus)
Postn (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 44 81.56 Quite High
cytokine 22 5.00 Very Low Very Low Very Low
anesthesia 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 352 99.60 Very High Very High Very High
Death 77 84.56 Quite High
Apoptosis 11 78.60 Quite High
Myocardial Infarction 11 50.08 Quite High
Congenital Anomalies 11 43.00 Quite Low
Infarction 11 41.80 Quite Low
Rupture 11 40.68 Quite Low
Adhesions 22 28.40 Quite Low
Infection 22 5.00 Very Low Very Low Very Low
Sprains And Strains 11 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although this physical association of periostin with the Notch1 precursor might be appropriate, by the Western blot analysis, we detected the N1™ of heterodimeric Notch1 in the wild-type molar PDL, whereas we could not detect its precursor.
Notch1 Spec (might) Binding (association) of periostin in molar
1) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
To investigate the effect of periostin on Notch signaling, we first examined whether periostin could physically associate with Notch1; because matricellular proteins often show their function through protein-protein interactions with cell-surface proteins [1].
Notch1 Binding (associate) of periostin in Notch
2) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.16 Pain Relevance 0
Next, we determined the domain of Notch1 that associated with periostin.
Notch1 Spec (determined) Binding (associated) of periostin
3) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
In this study, however, we reported that periostin physically associates with the Notch1 precursor at its EGF repeats in the inside of cells.
Notch1 Binding (associates) of periostin
4) Confidence 0.28 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923609 Disease Relevance 0.14 Pain Relevance 0
In the result, periostin was co-immunoprecipitated with EGF8-32, whereas it failed to be detected with NdEGF consisting of two different forms of NdEGF, i.e., the precursor form and the S1-cleaved heterodimeric form, indicating that periostin physically associated with the EGF repeats of Notch1.
Notch1 Binding (associated) of periostin
5) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
The data revealed the presence of the Notch1 precursor in the immunoprecipitate; however, S1-cleaved N1EC of heterodimeric Notch1 failed to be detected in the precipitate, indicating that periostin physically associated with the Notch1 precursor.
Notch1 Binding (associated) of periostin
6) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
The data revealed the presence of the Notch1 precursor in the immunoprecipitate; however, S1-cleaved N1EC of heterodimeric Notch1 failed to be detected in the precipitate, indicating that periostin physically associated with the Notch1 precursor.
Notch1 Binding (associated) of periostin
7) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
Different from this previous report, we propose that the Notch1 protein level is decreased under the oxidative stress condition but that periostin physically associates with the Notch1 precursor, and then maintains Notch1 protein expression and subsequent signaling under this stress condition.
Notch1 Binding (associates) of periostin associated with stress
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.89 Pain Relevance 0.07
To detect the association of Notch1 and periostin proteins, we performed immunoprecipitation of Notch1 by using anti-FLAG antibody followed by Western blot analysis using anti-periostin antibody, revealing the presence of periostin in the precipitate of Notch1 (Fig. 1B).
Notch1 Binding (presence) of periostin
9) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
To detect the association of Notch1 and periostin proteins, we performed immunoprecipitation of Notch1 by using anti-FLAG antibody followed by Western blot analysis using anti-periostin antibody, revealing the presence of periostin in the precipitate of Notch1 (Fig. 1B).
Notch1 Binding (presence) of periostin
10) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
Periostin physically associates with Notch1 precursor at its EGF repeats
Notch1 Binding (associates) of Periostin
11) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.23 Pain Relevance 0

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