INT327876

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Context Info
Confidence 0.56
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.92
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) embryo development (Notch1)
extracellular matrix organization (Postn) cytoplasm (Notch1) extracellular region (Postn)
Anatomy Link Frequency
stromal cell 2
Postn (Mus musculus)
Notch1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 16 63.52 Quite High
cytokine 8 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 128 99.58 Very High Very High Very High
Death 28 91.76 High High
Adhesions 8 5.00 Very Low Very Low Very Low
Infection 8 5.00 Very Low Very Low Very Low
Sprains And Strains 4 5.00 Very Low Very Low Very Low
Infarction 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Cadasil 4 5.00 Very Low Very Low Very Low
Congenital Anomalies 4 5.00 Very Low Very Low Very Low
Leukoencephalopathies 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further assess the effect of periostin on Notch1 expression, we established retroviral infectants of a bone marrow-derived stromal cell line, ST2, by using the periostin-HA construct and an AcGFP construct for a control.
periostin Regulation (effect) of Gene_expression (expression) of Notch1 in stromal cell
1) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.28 Pain Relevance 0
S1), suggesting that periostin might regulate Notch1 expression in various tissues that express periostin.
periostin Spec (might) Regulation (regulate) of Gene_expression (expression) of Notch1
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
This result suggests that periostin affected Notch1 expression in post-transcriptional manner.
periostin Regulation (affected) of Gene_expression (expression) of Notch1
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0 Pain Relevance 0
Our present results provide important insights into the regulation of Notch1 expression under the stress condition, and into periostin as a regulator of Notch1 expression, which is another unidentified function of periostin.


periostin Regulation (regulator) of Gene_expression (expression) of Notch1 associated with stress
4) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2923609 Disease Relevance 0.63 Pain Relevance 0.03

General Comments

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