INT327936

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Context Info
Confidence 0.61
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.62
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (F2rl1) signal transducer activity (F2rl1)
Anatomy Link Frequency
mast cells 2
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
allodynia 4 98.82 Very High Very High Very High
spastic colon 48 98.22 Very High Very High Very High
Hyperalgesia 4 86.76 High High
nud 8 85.76 High High
agonist 2 79.48 Quite High
Inflammation 14 76.52 Quite High
antagonist 10 54.72 Quite High
interstitial cystitis 2 47.28 Quite Low
pruritus 2 46.24 Quite Low
corticosteroid 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 92 99.98 Very High Very High Very High
Neuropathic Pain 4 98.82 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

46 98.22 Very High Very High Very High
Diarrhoea 6 97.90 Very High Very High Very High
Infection 16 89.28 High High
Hyperalgesia 4 86.76 High High
Dyspepsia 8 85.76 High High
INFLAMMATION 10 76.52 Quite High
Mucositis 4 57.44 Quite High
Disease 2 48.24 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mice, colonic exposure to supernatants from diarrhea-predominant IBS patients results in allodynia and increased colonic paracellular permeability, which is dependent on PAR2 expression (30).
Regulation (dependent) of Gene_expression (expression) of PAR2 associated with diarrhoea, allodynia and spastic colon
1) Confidence 0.61 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.11 Pain Relevance 0.74
Thus, in the present study, we aimed to evaluate whether acute restraint stress alters the numbers of mast cells and EC cells and PAR2 expression in the rat colon.
Spec (whether) Regulation (alters) of Gene_expression (expression) of PAR2 in mast cells associated with stress
2) Confidence 0.27 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.77 Pain Relevance 0.52

General Comments

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