INT32794

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Context Info
Confidence 0.68
First Reported 1985
Last Reported 2010
Negated 2
Speculated 2
Reported most in Body
Documents 81
Total Number 82
Disease Relevance 20.87
Pain Relevance 26.99

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2d) plasma membrane (Grin2d)
Anatomy Link Frequency
neurons 15
hippocampus 9
interneurons 5
brain 3
lamina 3
Grin2d (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 6685 100.00 Very High Very High Very High
antagonist 1244 100.00 Very High Very High Very High
GABAergic 286 99.84 Very High Very High Very High
Pain 198 99.72 Very High Very High Very High
Rostral ventromedial medulla 3 99.72 Very High Very High Very High
Central nervous system 13 99.68 Very High Very High Very High
antinociception 2 99.64 Very High Very High Very High
Inflammation 123 99.62 Very High Very High Very High
Dorsal horn 321 99.60 Very High Very High Very High
Glutamate 1129 99.46 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 4104 99.84 Very High Very High Very High
Pain 249 99.72 Very High Very High Very High
INFLAMMATION 124 99.62 Very High Very High Very High
Disease 330 99.38 Very High Very High Very High
Urological Neuroanatomy 520 99.36 Very High Very High Very High
Cognitive Disorder 900 98.84 Very High Very High Very High
Targeted Disruption 278 98.48 Very High Very High Very High
Cancer 76 97.98 Very High Very High Very High
Anxiety Disorder 72 97.24 Very High Very High Very High
Death 236 96.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The prolonged current decay kinetics observed in evoked whole cell NMDA currents in PrP-null mice are reminiscent of the slow current waveforms observed upon transient expression of NR1/NR2D receptors in tsA-201 cells (Vicini et al., 1998).
Gene_expression (expression) of NR2D
1) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
The expression of NR2D was measured using an antibody raised against a peptide mapping to the N terminus of the NR2D subunit (R-20; 1:200; Santa Cruz Biotechnology, Inc.) and an HRP-conjugated donkey anti–goat (1:1,000; Jackson ImmunoResearch Laboratories).
Gene_expression (expression) of NR2D
2) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
80% of NR2D protein expressed at the cell surface.
Gene_expression (expressed) of NR2D protein
3) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.04
WT and PrP-null mouse neurons both expressed NR2D subunit mRNA and protein, with ?
Gene_expression (expressed) of NR2D subunit in neurons
4) Confidence 0.68 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.04
The expression of NR1 and all subunits of NR2 family (NR2A, NR2B, NR2C, NR2D) of NMDA receptor complex was examined using immunoblotting method.
Spec (examined) Gene_expression (expression) of NR2D associated with nmda receptor
5) Confidence 0.63 Published 2007 Journal Drug Alcohol Depend Section Abstract Doc Link 16930867 Disease Relevance 0.36 Pain Relevance 1.40
Expression of NR2D subunits in WT and PrP-null mice
Gene_expression (Expression) of NR2D
6) Confidence 0.60 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.05 Pain Relevance 0.03
For NR2D RNAi experiments, we used the following shRNAmir constructs: clone ID TRCN0000100210, TRCN0000100211, TRCN0000100212, TRCN0000100213, and TRCN0000100214.
Gene_expression (experiments) of NR2D
7) Confidence 0.59 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0
Early postnatal chronic inflammation produces long-term changes in pain behavior and N-methyl-D-aspartate receptor subtype gene expression in the central nervous system of adult mice.
Gene_expression (expression) of N-methyl-D-aspartate receptor subtype gene in central nervous system associated with pain, inflammation, nmda receptor and central nervous system
8) Confidence 0.59 Published 2006 Journal J. Neurosci. Res. Section Title Doc Link 17016858 Disease Relevance 0.59 Pain Relevance 0.83
An N-methyl-D-aspartate-receptor antagonist but not a tachykinin-NK1-receptor antagonist produced greater antinociception in vincristine-treated mice.
Gene_expression (produced) of N-methyl-D-aspartate-receptor associated with vincristine, antinociception and antagonist
9) Confidence 0.58 Published 2003 Journal Neurosci. Lett. Section Abstract Doc Link 12759171 Disease Relevance 0.50 Pain Relevance 1.13
The mostly excitatory, EGFP- neurons mainly express NR2A/B containing receptors with minimal evidence for NR2C/D subunit expression.
Gene_expression (expression) of NR2C/D in neurons
10) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0.09 Pain Relevance 0.34
As shown in Figure 5C, the ratios of both subpopulations of interneurons were close to those of NMDA receptors with high Mg2+ sensitivity, suggesting that mainly NR2A/B, not NR2C/D subunits, are synaptically expressed on both EGFP+ (0.09 ± 0.01, n = 18) and EGFP- neurons (0.09 ± 0.01, n = 19).
Neg (not) Gene_expression (expressed) of NR2C/D in neurons associated with nmda receptor
11) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.27
The differential expression of NR2D containing NMDA receptors on lamina II inhibitory interneurons compared to excitatory interneurons suggests a role for NR2D containing NMDA receptors in modulating the activity of inhibitory interneurons.


Gene_expression (expression) of NR2D in interneurons associated with nmda receptor
12) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0.53 Pain Relevance 0.78
We did not see significant evidence for NR2C/D subunit expression by excitatory interneurons.
Gene_expression (expression) of NR2C/D in interneurons
13) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.14
Our results suggest that NR2D containing NMDA receptors are likely to be expressed at extrasynaptic regions on inhibitory interneurons.
Gene_expression (expressed) of NR2D in inhibitory interneurons associated with nmda receptor
14) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0.09 Pain Relevance 0.50
Consistent with this difference in conductance ratio, average VMIC of EGFP- neurons is significantly more positive than in EGFP+ neurons (-43 ± 2 mV vs - 48 ± 2 mV, n = 11, p < 0.05), indicating that EGFP- neurons dominantly express a higher percentage of NR2A/B type NMDA receptors and less NR2C/D than EGFP+ cells.
Gene_expression (express) of NR2C/D in neurons associated with nmda receptor
15) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.38
This allowed us to use luminometry to quantify the fraction of NR2D subunits expressed at the cell surface relative to total NR2D expression by comparing immunoreactivity in permeabilized and nonpermeabilized cells.
Gene_expression (expressed) of NR2D
16) Confidence 0.53 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.09 Pain Relevance 0
Collectively, these data indicate that hippocampal neurons in both WT and PrP-null mice express similar levels of NR2D surface protein, with no apparent differences in subcellular distributions of NR2D subunits.
Neg (no) Gene_expression (express) of NR2D in neurons
17) Confidence 0.53 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.15 Pain Relevance 0
This allowed us to use luminometry to quantify the fraction of NR2D subunits expressed at the cell surface relative to total NR2D expression by comparing immunoreactivity in permeabilized and nonpermeabilized cells.
Gene_expression (expression) of NR2D
18) Confidence 0.53 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0.09 Pain Relevance 0
Because isolated NR2 subunits do not traffic to the plasma membrane unless they are in a complex with an NR1 subunit (Dunah et al., 1998; Cull-Candy and Leszkiewicz, 2004), the NR2D receptors expressed in the plasma membrane of WT mouse neurons are likely part of fully assembled NMDAR complexes.
Gene_expression (expressed) of NR2D in plasma
19) Confidence 0.53 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.03
Expression of NR2D subunits in WT and PrP-null mice
Gene_expression (subunits) of NR2D
20) Confidence 0.52 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2364707 Disease Relevance 0 Pain Relevance 0.03

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