INT327940

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Context Info
Confidence 0.44
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 5.57
Pain Relevance 2.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) plasma membrane (F2rl1)
signal transducer activity (F2rl1) response to stress (Crh) cytoplasm (Crh)
Anatomy Link Frequency
mast cells 6
colon 2
Crh (Rattus norvegicus)
F2rl1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 20 98.20 Very High Very High Very High
spastic colon 96 96.44 Very High Very High Very High
Inflammation 28 93.92 High High
nud 16 89.36 High High
allodynia 8 77.76 Quite High
Hyperalgesia 8 66.88 Quite High
agonist 4 66.24 Quite High
interstitial cystitis 4 56.44 Quite High
pruritus 4 55.40 Quite High
corticosteroid 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 184 100.00 Very High Very High Very High
Infection 32 98.44 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

92 96.44 Very High Very High Very High
INFLAMMATION 20 93.92 High High
Hypersensitivity 4 92.56 High High
Dyspepsia 16 89.36 High High
Neuropathic Pain 8 77.76 Quite High
Diarrhoea 12 75.92 Quite High
Hyperalgesia 8 66.88 Quite High
Mucositis 8 66.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We speculate that a 90 min restraint session permits the release of CRF, which is able to increase mast cells and PAR2 expression in the colon.
CRF Positive_regulation (increase) of Gene_expression (expression) of PAR2 in mast cells
1) Confidence 0.44 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.17 Pain Relevance 0.80
Thus, it is plausible that CRF released during acute stress increases mast cell numbers and degranulates mast cells, which upregulates PAR2 expression in the colon.
CRF Positive_regulation (upregulates) of Gene_expression (expression) of PAR2 in colon associated with stress
2) Confidence 0.41 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.02 Pain Relevance 0.63
We hypothesized that CRF released by stress may increase the numbers of mast cells in the colon and enhance protease-activated receptor 2 (PAR2) expression in the colon.
CRF Positive_regulation (enhance) of Gene_expression (expression) of protease-activated receptor 2 in mast cells associated with stress
3) Confidence 0.41 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 1.04 Pain Relevance 0.70
Thus, these results suggest that CRF released by acute stress mediates increase in mast cell numbers and PAR2 expression.
CRF Positive_regulation (mediates) of Gene_expression (expression) of PAR2 in mast cell associated with stress
4) Confidence 0.41 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923781 Disease Relevance 0.88 Pain Relevance 0.37

General Comments

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