INT327947

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Context Info
Confidence 0.76
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 1.96
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv5) transmembrane transport (Trpv5)
Trpv5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Kidney Stones 144 99.82 Very High Very High Very High
Targeted Disruption 36 96.60 Very High Very High Very High
Apoptosis 9 83.56 Quite High
Body Weight 36 79.64 Quite High
Weight Gain 9 34.72 Quite Low
Volume Depletion And Dehydration 18 33.16 Quite Low
Hypercalcemia 9 9.60 Low Low
Hematuria 9 8.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When high calcium diet and supraphysiologic vitamin D3 were administered concomitantly, severe hypercalciuria was induced and TRPV5 expression was suppressed in protein levels.
Gene_expression (expression) of TRPV5 associated with kidney stones
1) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.22 Pain Relevance 0
In our experiment, high calcium diet and vitamin D3 decreased protein abundance of TRPV5, NHE3, SGLT1, and NKCC2, resulting in severe hypercalciuria and the expression of TRPV5, NHE3, and NKCC2 was not restored by HCTZ administration.
Gene_expression (expression) of TRPV5 associated with kidney stones
2) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.19 Pain Relevance 0
To assess the effect of thiazides on the transporters participating in the passive and active calcium reabsorption under severe hypercalciuric condition, the expression of NHE3 and SGLT1 on the PT, NKCC2 on the TAL, and TRPV5 and calbindin-D28K on the DCT was analyzed.


Spec (analyzed) Gene_expression (expression) of TRPV5
3) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.28 Pain Relevance 0
In this study, male rats were used to minimize the effect of estrogen on TRPV5 expression and high calcium diet with vitamin D was administered to elucidate the effect of supraphysiologic vitamin D3 on the hypocalciuric effect of thiazide.
Gene_expression (expression) of TRPV5
4) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.32 Pain Relevance 0
They reported that HCTZ-induced hypocalciuria seems to be achieved through the increased expression of TRPV5 under euvolemic condition and this is consistent with our previous report.
Gene_expression (expression) of TRPV5
5) Confidence 0.76 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.24 Pain Relevance 0
We also revealed that the hypocalciuric effect of HCTZ is attenuated in high calcium diet and vitamin D-induced hypercalciuric rats, probably caused by persistently decreased TRPV5 protein abundance.
Gene_expression (abundance) of TRPV5 protein
6) Confidence 0.66 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.09 Pain Relevance 0
Hoenderop et al. reported that TRPV5 is an important target of active vitamin D3 and is positively controlled by vitamin D3 through experiments using vitamin D-deficient diet (15) and 25-hydroxyvitamin D3-1?
Gene_expression (controlled) of TRPV5
7) Confidence 0.66 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.34 Pain Relevance 0
The hypocalciuric effect of hydrochlorothiazide (HCTZ) and the expression of transient receptor potential vanilloid 5 (TRPV5), calbindin-D28K, and several sodium transporters were assessed in hypercalciuric rats induced by high calcium diet and vitamin D3.
Gene_expression (expression) of TRPV5
8) Confidence 0.59 Published 2010 Journal Journal of Korean Medical Science Section Abstract Doc Link PMC2923802 Disease Relevance 0.10 Pain Relevance 0
Expression of TRPV5 and calbindin-D28K mRNA significantly decreased in the high Ca-vitamin D group, which increased when HCTZ was administered (Figs. 3, 4).
Gene_expression (Expression) of TRPV5
9) Confidence 0.59 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.19 Pain Relevance 0

General Comments

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