INT32795

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Context Info
Confidence 0.15
First Reported 1985
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 20.16
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma 1
skeletal muscle 1
neuronal 1
blood 1
pancreas 1
Hypism (Mus musculus)
Pain Link Frequency Relevance Heat
narcan 11 99.54 Very High Very High Very High
withdrawal 4 99.54 Very High Very High Very High
Inflammation 127 97.64 Very High Very High Very High
anesthesia 8 89.12 High High
Pain score 1 85.36 High High
spinal-cord stimulation 4 82.24 Quite High
cytokine 52 78.52 Quite High
tolerance 45 77.16 Quite High
ischemia 4 77.08 Quite High
noradrenaline 2 76.96 Quite High
Disease Link Frequency Relevance Heat
Obesity 307 100.00 Very High Very High Very High
Metabolic Syndrome 214 100.00 Very High Very High Very High
Insulin Resistance 214 100.00 Very High Very High Very High
Hyperinsulinism 72 100.00 Very High Very High Very High
Hyperlipidemia 23 100.00 Very High Very High Very High
Hyperglycemia 36 99.84 Very High Very High Very High
Hypoglycemia 15 99.80 Very High Very High Very High
Cancer 95 99.72 Very High Very High Very High
Impaired Glucose Tolerance 46 99.56 Very High Very High Very High
Targeted Disruption 211 99.34 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, a key discovery of these experiments, and of particular relevance to this study, was that a very low level of ubiquitous agouti expression did not cause obesity or hyperinsulinemia, but was sufficient to promote carcinogenesis in some tissues.
Neg (not) Positive_regulation (cause) of hyperinsulinemia associated with obesity and hyperinsulinism
1) Confidence 0.15 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 1.06 Pain Relevance 0
Remarkably, for our purpose, an osteoblast-specific ablation of sympathetic signaling results in a leptin-dependent hyperinsulinemia.
Positive_regulation (results) of hyperinsulinemia in osteoblast associated with hyperinsulinism and osteoporosis
2) Confidence 0.15 Published 2008 Journal The Journal of Cell Biology Section Abstract Doc Link PMC2606962 Disease Relevance 0.61 Pain Relevance 0
HFD-fed 12/15LO KO mice did exhibit a similar fold increase in eWAT mass but not hyperinsulinemia, compared to HFD-fed WT mice (Table 1).
Positive_regulation (increase) of hyperinsulinemia associated with targeted disruption and hyperinsulinism
3) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.52 Pain Relevance 0.06
Two-week high fat feeding induced hyperinsulinemia and severe hepatic and skeletal muscle insulin resistance in WT but not 12/15LO KO mice. 12/15LO KO mice exhibited significantly greater insulin-stimulated skeletal muscle Akt phosphorylation after HFD, compared to WT mice, corresponding to their greater insulin sensitivity.
Positive_regulation (induced) of hyperinsulinemia in skeletal muscle associated with targeted disruption, hyperinsulinism and insulin resistance
4) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2746280 Disease Relevance 1.91 Pain Relevance 0.27
Fetal hypoglycemia and hypoinsulinemia were produced by inducing maternal hyperinsulinemia and hypoglycemia secondary to the exogenous administration of insulin via implantation of osmotically driven minipumps on day 15 of gestation into 15 experimental animals. 13 animals served as sham-operated controls.
Positive_regulation (inducing) of hyperinsulinemia associated with hypoglycemia and hyperinsulinism
5) Confidence 0.09 Published 1985 Journal Biol. Neonate Section Abstract Doc Link 2983786 Disease Relevance 0.39 Pain Relevance 0.08
These include increasing age, increasing body mass index (BMI), hyperinsulinemia, insulin resistance, type 2 diabetes, and polycystic ovary syndrome.
Positive_regulation (increasing) of hyperinsulinemia in ovary associated with diabetes mellitus, obesity, polycystic ovary syndrome, hyperinsulinism and insulin resistance
6) Confidence 0.08 Published 2002 Journal Am. J. Surg. Section Abstract Doc Link 12527345 Disease Relevance 1.20 Pain Relevance 0.09
High plasma GH levels induce hyperinsulinemia and insulin resistance [12, 46].
Positive_regulation (induce) of hyperinsulinemia in plasma associated with hyperinsulinism and insulin resistance
7) Confidence 0.06 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.50 Pain Relevance 0
Estrogen withdrawal in these animals also induces fasting and glucose-stimulated hyperinsulinemia, which are signs of worsening insulin resistance.
Positive_regulation (induces) of hyperinsulinemia associated with hyperinsulinism, insulin resistance and withdrawal
8) Confidence 0.04 Published 1996 Journal Am. J. Hypertens. Section Abstract Doc Link 8972891 Disease Relevance 0.74 Pain Relevance 0.27
Namely, the well documented hyperinsulinemia story and the more recent hyperamylinemia and amylin derived islet amyloid story. [8,9]
Positive_regulation (documented) of hyperinsulinemia associated with alzheimer's dementia and hyperinsulinism
9) Confidence 0.03 Published 2002 Journal Cardiovasc Diabetol Section Body Doc Link PMC140143 Disease Relevance 1.43 Pain Relevance 0
Naloxone potentiated endotoxin-induced hyperinsulinemia and insulin hypersecretion from the endotoxic pancreas in fed, but not fasted, rats.
Positive_regulation (induced) of hyperinsulinemia in pancreas associated with narcan and hyperinsulinism
10) Confidence 0.02 Published 1988 Journal Circ. Shock Section Abstract Doc Link 3061683 Disease Relevance 0.34 Pain Relevance 0.55
Therefore, we investigated influence of acute hyperglycemia and/or hyperinsulinemia induced by glucose or insulin infusion on neuronal and humoral control of vascular tone in rats.
Positive_regulation (induced) of hyperinsulinemia in neuronal associated with hyperglycemia and hyperinsulinism
11) Confidence 0.02 Published 2008 Journal Yakugaku Zasshi Section Abstract Doc Link 18311062 Disease Relevance 0.64 Pain Relevance 0.28
Hypoglycemia may be caused by quinine- or quinidine-induced hyperinsulinemia, but it may be found also in patients with normal insulin levels.


Positive_regulation (induced) of hyperinsulinemia associated with hypoglycemia and hyperinsulinism
12) Confidence 0.01 Published 2003 Journal Crit Care Section Body Doc Link PMC270697 Disease Relevance 2.74 Pain Relevance 0.07
Thus, in this model energy (glucose, triglycerides) is not removed from systemic circulation effectively despite elevated insulin (hyperinsulinemia reflecting insulin resistance), which leads to a blood glucose increase that eventually leads to beta-cell failure with decreased insulin production [47,49,50].
Positive_regulation (elevated) of hyperinsulinemia in blood associated with hyperinsulinism and insulin resistance
13) Confidence 0.01 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2868017 Disease Relevance 0.87 Pain Relevance 0
Multiple abnormalities that can lead to kidney injury have been identified in overweight and obese people, including insulin resistance, compensatory hyperinsulinemia, inappropriate activation of the renin-angiotensin-aldosterone system, increased oxidative stress, endoplasmic reticulum stress, coagulability, and impaired fibrinolysis.
Positive_regulation (activation) of hyperinsulinemia in reticulum associated with stress, reprotox - general 3, obesity, injury, hyperinsulinism, insulin resistance and overweight
14) Confidence 0.01 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3014711 Disease Relevance 2.18 Pain Relevance 0.03
The Indian Experiments of Infarct Survival
         Acute myocardial infarction(AMI) is associated with hyperglycemia, hypertrigly- ceridemia, hyperinsulinemia, increased FFA, free radical stress, IL-6, TNF-alpha, and deficiency of antioxidant vitamins and w-3 fatty acids, which appear to be responsible for complications and deaths among these patients [27, 112, 113, 117–127]. 
Positive_regulation (increased) of hyperinsulinemia associated with stress, hyperglycemia, hyperinsulinism and myocardial infarction
15) Confidence 0.01 Published 2010 Journal Cardiology Research and Practice Section Body Doc Link PMC2910415 Disease Relevance 1.54 Pain Relevance 0.04
Moderate hypertension, glucose intolerance, insulin resistance, hyperinsulinemia and hypertriglyceridemia, which are signs of metabolic syndrome, were induced in rats by prolonged feeding with high-fructose diets [11,12].
Positive_regulation (induced) of hyperinsulinemia associated with hypertension, metabolic syndrome, hyperinsulinism, hyperlipidemia, insulin resistance and impaired glucose tolerance
16) Confidence 0.01 Published 2011 Journal Lipids Health Dis Section Body Doc Link PMC3024237 Disease Relevance 1.46 Pain Relevance 0
This review focuses on diet and inactivity as major factors for cancer promotion by inducing insulin resistance and hyperinsulinemia.
Positive_regulation (inducing) of hyperinsulinemia associated with cancer, hyperinsulinism and insulin resistance
17) Confidence 0.01 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Abstract Doc Link PMC538507 Disease Relevance 1.03 Pain Relevance 0

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