INT327953

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Context Info
Confidence 0.68
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Trpv5) transmembrane transport (Trpv5)
Trpv5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Kidney Stones 48 99.82 Very High Very High Very High
Targeted Disruption 12 91.80 High High
Apoptosis 3 83.96 Quite High
Weight Gain 3 37.56 Quite Low
Volume Depletion And Dehydration 6 36.00 Quite Low
Body Weight 12 24.88 Low Low
Hematuria 3 5.00 Very Low Very Low Very Low
Hypercalcemia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They reported that HCTZ-induced hypocalciuria seems to be achieved through the increased expression of TRPV5 under euvolemic condition and this is consistent with our previous report.
Positive_regulation (increased) of Gene_expression (expression) of TRPV5
1) Confidence 0.68 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.24 Pain Relevance 0
We also revealed that the hypocalciuric effect of HCTZ is attenuated in high calcium diet and vitamin D-induced hypercalciuric rats, probably caused by persistently decreased TRPV5 protein abundance.
Positive_regulation (induced) of Gene_expression (abundance) of TRPV5 protein
2) Confidence 0.49 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.09 Pain Relevance 0
In our experiment, high calcium diet and vitamin D3 decreased protein abundance of TRPV5, NHE3, SGLT1, and NKCC2, resulting in severe hypercalciuria and the expression of TRPV5, NHE3, and NKCC2 was not restored by HCTZ administration.
Neg (not) Positive_regulation (restored) of Gene_expression (expression) of TRPV5 associated with kidney stones
3) Confidence 0.46 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2923802 Disease Relevance 0.20 Pain Relevance 0

General Comments

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