INT32796

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.36
First Reported 1985
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 9
Disease Relevance 2.44
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (G6pc)
Anatomy Link Frequency
hepatocytes 2
liver 1
bile 1
G6pc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 183 98.88 Very High Very High Very High
anesthesia 6 94.76 High High
Paracetamol 6 80.44 Quite High
Inflammation 2 76.80 Quite High
agonist 9 67.44 Quite High
dexamethasone 6 5.00 Very Low Very Low Very Low
adenocard 5 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
nud 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Fistula 57 98.68 Very High Very High Very High
Toxicity 7 88.48 High High
Diabetes Mellitus 47 85.20 High High
Hypoglycemia 3 83.04 Quite High
Hyperinsulinism 1 82.36 Quite High
Reprotox - General 3 1 81.04 Quite High
INFLAMMATION 2 77.52 Quite High
Injury 9 76.08 Quite High
Hypertrophy 2 61.92 Quite High
Edema 2 60.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the hyperinsulinemic mothers had suppressed hepatic glucose-6-phosphatase activity.
Negative_regulation (suppressed) of glucose-6-phosphatase
1) Confidence 0.36 Published 1985 Journal Biol. Neonate Section Abstract Doc Link 2983786 Disease Relevance 0.32 Pain Relevance 0.09
Thus, acute inhibition of glucose-6-phosphatase activity by S4048 elicited 1) a repartitioning of newly synthesized Glc-6-P from glucose production into glycogen synthesis without affecting the gluconeogenic flux to Glc-6-P and 2) a cellular response aimed at maintaining cellular Glc-6-P homeostasis.
Negative_regulation (inhibition) of glucose-6-phosphatase
2) Confidence 0.27 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11346646 Disease Relevance 0 Pain Relevance 0
Effects of acute inhibition of glucose-6-phosphatase activity by the chlorogenic acid derivative S4048 on hepatic carbohydrate fluxes were examined in isolated rat hepatocytes and in vivo in rats.
Negative_regulation (inhibition) of glucose-6-phosphatase in hepatocytes
3) Confidence 0.27 Published 2001 Journal J. Biol. Chem. Section Abstract Doc Link 11346646 Disease Relevance 0 Pain Relevance 0.15
Acute inhibition of hepatic glucose-6-phosphatase does not affect gluconeogenesis but directs gluconeogenic flux toward glycogen in fasted rats.
Negative_regulation (inhibition) of glucose-6-phosphatase
4) Confidence 0.24 Published 2001 Journal J. Biol. Chem. Section Title Doc Link 11346646 Disease Relevance 0 Pain Relevance 0.16
(28), resulting in the downregulation of PEPCK and G-6-Pase.
Negative_regulation (downregulation) of G-6-Pase
5) Confidence 0.20 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.29 Pain Relevance 0.14
Downregulation of PEPCK and G-6-Pase mRNA by TCA in the chronic bile fistula rat and primary rat hepatocytes
Negative_regulation (Downregulation) of G-6-Pase in hepatocytes associated with bile and fistula
6) Confidence 0.20 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.25 Pain Relevance 0.32
The data show a very rapid downregulation of both PEPCK and G-6-Pase mRNA following the infusion of TCA in the chronic bile fistula rat (Fig. 2).
Negative_regulation (downregulation) of G-6-Pase in bile associated with bile and fistula
7) Confidence 0.20 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.35 Pain Relevance 0.37
Treated groups exhibited a significant decrease in the levels of glucose-6-phosphatase (Fig. 4) and alanine amino transferase (Fig. 5).
Negative_regulation (decrease) of glucose-6-phosphatase
8) Confidence 0.14 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1193540 Disease Relevance 0.43 Pain Relevance 0
Feeding of allicin (100 mg/kg/day) for 15 days in rats increased the activity of liver lipase and alpha glucal phosphorylase and decreased glucose-6-phosphatase activity [163].
Negative_regulation (decreased) of glucose-6-phosphatase in liver
9) Confidence 0.01 Published 2002 Journal Nutr J Section Body Doc Link PMC139960 Disease Relevance 0.80 Pain Relevance 0.04

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox