INT32797

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.28
First Reported 1985
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 1.63
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (G6pc)
Anatomy Link Frequency
hepatocytes 2
bile 2
G6pc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 305 99.42 Very High Very High Very High
agonist 15 85.84 High High
anesthesia 6 66.96 Quite High
dexamethasone 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoglycemia 3 100.00 Very High Very High Very High
Fistula 95 99.16 Very High Very High Very High
Hyperinsulinism 1 92.24 High High
Bordatella Infection 15 61.28 Quite High
Toxicity 5 49.12 Quite Low
Repression 20 15.84 Low Low
Van Bogaert's Disease 15 5.00 Very Low Very Low Very Low
Vesicular Stomatitis 5 5.00 Very Low Very Low Very Low
Biliary Fistula 5 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To further investigate the mechanism of regulation of PEPCK and G-6-Pase mRNA by TCA, we used primary rat hepatocytes as a model.
Spec (investigate) Regulation (regulation) of G-6-Pase in hepatocytes
1) Confidence 0.28 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.23 Pain Relevance 0.26
In the current study, the chronic bile fistula (CBF) rat model and primary rat hepatocytes (PRH) were used to study the regulation of gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) and the gene encoding short heterodimeric partner (SHP) by taurocholate (TCA).
Regulation (regulation) of G-6-Pase in bile associated with bile and fistula
2) Confidence 0.21 Published 2010 Journal Journal of Lipid Research Section Abstract Doc Link PMC2903791 Disease Relevance 0.35 Pain Relevance 0.13
We measured the effect of TCA on the regulation of PEPCK and G-6-Pase in the chronic bile fistula rat and in primary hepatocytes.
Regulation (regulation) of G-6-Pase in hepatocytes associated with bile and fistula
3) Confidence 0.21 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.35 Pain Relevance 0.35
The effect of fetal hypoglycemia and hypoinsulinemia on fetal rat hepatic glucose-6-phosphatase activity was studied.
Regulation (effect) of glucose-6-phosphatase associated with hypoglycemia
4) Confidence 0.16 Published 1985 Journal Biol. Neonate Section Abstract Doc Link 2983786 Disease Relevance 0.38 Pain Relevance 0.07
As we also know that PTX does not affect the ability of TCA to enter the cell (19), these results suggest that TCA can regulate G-6-Pase and PEPCK-1 mRNA through GPCR(s), which we have shown to activate the PI3K/PDK-1/AKT signaling cascade (17–20).
Regulation (regulate) of G-6-Pase
5) Confidence 0.12 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.07 Pain Relevance 0.09
Bile acids have been reported to regulate the rate-limiting gluconeogenic genes phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) in various cell culture and animal models (4, 23–28).
Regulation (regulate) of G-6-Pase in Bile associated with bile
6) Confidence 0.12 Published 2010 Journal Journal of Lipid Research Section Body Doc Link PMC2903791 Disease Relevance 0.26 Pain Relevance 0.33

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox