INT32798

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Context Info
Confidence 0.49
First Reported 1985
Last Reported 1999
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.25
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (G6pc)
Anatomy Link Frequency
Liver 1
G6pc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 3 99.68 Very High Very High Very High
Paracetamol 2 96.28 Very High Very High Very High
methadone 3 86.88 High High
addiction 2 86.08 High High
tolerance 1 75.88 Quite High
Disease Link Frequency Relevance Heat
Hypoglycemia 9 98.12 Very High Very High Very High
Poisoning 1 94.40 High High
Hyperinsulinism 3 91.24 High High
Impaired Glucose Tolerance 1 75.88 Quite High
Body Weight 1 66.32 Quite High
Diabetes Mellitus 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hepatocytolysis was determined by measuring the level of serum transaminases (GPT and GOT), steatosis by Sudan black staining, histological structures by hamatoxylineosin staining and the activity of enzymes such as SDH, GtDH, G-6-Pase and ATPase.
Spec (determined) Positive_regulation (measuring) of G-6-Pase
1) Confidence 0.49 Published 1999 Journal Phytother Res Section Abstract Doc Link 10190184 Disease Relevance 0.09 Pain Relevance 0.17
Induction in utero of hepatic glucose-6-phosphatase by fetal hypoinsulinemia.
Positive_regulation (Induction) of glucose-6-phosphatase
2) Confidence 0.48 Published 1985 Journal Biol. Neonate Section Title Doc Link 2983786 Disease Relevance 0.37 Pain Relevance 0.08
Hypoinsulinemia would appear to be the primary stimulus for enhanced fetal glucose-6-phosphatase in this model.
Positive_regulation (enhanced) of glucose-6-phosphatase
3) Confidence 0.48 Published 1985 Journal Biol. Neonate Section Abstract Doc Link 2983786 Disease Relevance 0.30 Pain Relevance 0.09
The specific activities of two gluconeogenic enzymes-glucose-6-phosphatase and fructose-1,6-biphosphatase-were significantly elevated in the drug-exposed animals compared to controls, whereas the activity of a third enzyme-phosphoenolpyruvate carboxykinase-was unchanged.
Positive_regulation (elevated) of glucose-6-phosphatase
4) Confidence 0.45 Published 1997 Journal Gen. Pharmacol. Section Abstract Doc Link 9112073 Disease Relevance 0.14 Pain Relevance 0.34
Liver glucose-6-phosphatase activity was increased in the hypoinsulinemic fetuses.
Positive_regulation (increased) of glucose-6-phosphatase in Liver
5) Confidence 0.28 Published 1985 Journal Biol. Neonate Section Abstract Doc Link 2983786 Disease Relevance 0.34 Pain Relevance 0.10

General Comments

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