INT327994

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Context Info
Confidence 0.05
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ROS1) cell proliferation (ROS1) extracellular space (Il6)
aging (Il6) extracellular region (Il6) plasma membrane (ROS1)
Anatomy Link Frequency
fibroblasts 2
Il6 (Rattus norvegicus)
ROS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 2 99.28 Very High Very High Very High
antagonist 11 96.76 Very High Very High Very High
cytokine 2 95.92 Very High Very High Very High
Inflammation 41 84.12 Quite High
rheumatoid arthritis 1 79.36 Quite High
qutenza 13 72.00 Quite High
agonist 8 71.60 Quite High
imagery 14 64.12 Quite High
Osteoarthritis 3 60.56 Quite High
Lasting pain 1 36.44 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 22 88.56 High High
INFLAMMATION 34 84.12 Quite High
Rheumatoid Arthritis 1 79.36 Quite High
Osteoarthritis 3 60.56 Quite High
Nociception 15 50.00 Quite Low
Pain 7 36.44 Quite Low
Fever 2 23.16 Low Low
Pressure And Volume Under Development 1 20.88 Low Low
Targeted Disruption 2 7.20 Low Low
Hyperalgesia 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, ROS production in synovial fibroblasts harvested from patients has been shown in a previous study to be increased significantly by IL-6 and inhibited by methotrexate [27].
IL-6 Positive_regulation (increased) of Gene_expression (production) of ROS in fibroblasts associated with methotrexate
1) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.55 Pain Relevance 0.73

General Comments

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