INT327995

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Context Info
Confidence 0.16
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.63
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) extracellular space (Tnfrsf1a) transport (TRPV1)
extracellular region (Tnfrsf1a) nucleus (Tnfrsf1a) plasma membrane (TRPV1)
Anatomy Link Frequency
dorsal root ganglia 2
TRPV1 (Homo sapiens)
Tnfrsf1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 3 91.92 High High
Osteoarthritis 3 91.00 High High
Inflammation 41 87.16 High High
cytokine 2 85.16 High High
rheumatoid arthritis 1 81.84 Quite High
methotrexate 2 77.60 Quite High
antagonist 11 62.08 Quite High
Spinal cord 21 37.68 Quite Low
qutenza 13 37.32 Quite Low
agonist 8 36.92 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 34 91.92 High High
Osteoarthritis 3 91.00 High High
Rheumatoid Arthritis 1 81.84 Quite High
Arthritis 22 76.80 Quite High
Nociception 15 50.00 Quite Low
Hyperalgesia 6 18.32 Low Low
Injury 3 5.76 Low Low
Pain 7 5.00 Very Low Very Low Very Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Arthropathy 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
induces increases in TRPV1 in synoviocytes [19], and that TRPV1 activation increases TNF receptors (TNFR1) in dorsal root ganglia (DRG) through a ROS mediated signalling pathway [29].
Positive_regulation (activation) of TRPV1 in dorsal root ganglia Positive_regulation (increases) of TNFR1
1) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2924298 Disease Relevance 0.63 Pain Relevance 0.46

General Comments

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