INT32802

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.57
First Reported 1980
Last Reported 2007
Negated 0
Speculated 2
Reported most in Abstract
Documents 21
Total Number 22
Disease Relevance 4.03
Pain Relevance 14.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ada) extracellular space (Ada) aging (Ada)
cell adhesion (Ada) plasma membrane (Ada) lysosome (Ada)
Anatomy Link Frequency
spinal 3
spinal cord 3
medial 3
plasma 1
Ada (Rattus norvegicus)
Pain Link Frequency Relevance Heat
adenocard 240 100.00 Very High Very High Very High
Spinal cord 18 99.92 Very High Very High Very High
Paracetamol 5 99.84 Very High Very High Very High
antinociception 32 99.60 Very High Very High Very High
Inflammation 18 99.60 Very High Very High Very High
Antinociceptive 29 99.32 Very High Very High Very High
depression 2 99.24 Very High Very High Very High
Thermal hyperalgesia 11 98.88 Very High Very High Very High
Pain 8 98.88 Very High Very High Very High
IPN 3 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 20 99.60 Very High Very High Very High
Depression 2 99.24 Very High Very High Very High
Hyperalgesia 11 98.88 Very High Very High Very High
Pain 3 98.88 Very High Very High Very High
Inflammatory Pain 3 98.80 Very High Very High Very High
Pneumonia 1 97.48 Very High Very High Very High
Infection 2 97.08 Very High Very High Very High
Severe Combined Immunodeficiency 3 95.64 Very High Very High Very High
Nociception 1 90.76 High High
Headache 1 89.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such a local environment may also limit diffusion of exogenously added adenosine towards the active zones, as we showed that this constrain may be overcome by inhibiting ADA activity with erythro-9(2-hydroxy-3-nonyl) adenine (50 microM).
Negative_regulation (inhibiting) of ADA associated with adenocard
1) Confidence 0.57 Published 2006 Journal Auton Neurosci Section Abstract Doc Link 16563876 Disease Relevance 0 Pain Relevance 0.35
It was found that all investigated drugs inhibit ADA activity in plasma and ADA2 isoenzyme is responsible for this inhibition.
Spec (investigated) Negative_regulation (inhibit) of ADA in plasma
2) Confidence 0.55 Published 2006 Journal Pol. Arch. Med. Wewn. Section Abstract Doc Link 18652275 Disease Relevance 0.15 Pain Relevance 0.55
Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor.
Negative_regulation (inhibitor) of adenosine deaminase associated with adenocard, inflammation and antinociceptive
3) Confidence 0.44 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10611432 Disease Relevance 0.58 Pain Relevance 1.31
These results provide evidence for a predominantly spinal antinociceptive effect and a predominantly peripheral anti-inflammatory effect produced by inhibitors of adenosine kinase and adenosine deaminase.
Negative_regulation (inhibitors) of adenosine deaminase in spinal associated with adenocard, inflammation and antinociceptive
4) Confidence 0.44 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10611432 Disease Relevance 0.30 Pain Relevance 0.73
In contrast to previous reports on the requirement of the copresence of adenosine for alpha receptor stimulated accumulation of cyclic AMP in neuronal tissue, the PE-stimulation in spinal cord slices was unchanged by adenosine receptor blockade (theophylline), hydrolysis of endogenous adenosine (adenosine deaminase), inhibition of adenosine deaminase (EHNA) or blockade of adenosine uptake (dipyridamole).
Negative_regulation (inhibition) of adenosine deaminase in spinal cord associated with adenocard and spinal cord
5) Confidence 0.44 Published 1980 Journal J Cyclic Nucleotide Res Section Abstract Doc Link 6106025 Disease Relevance 0 Pain Relevance 0.69
RT-PCR and RT-PCR-Southern blotting were used to examine the relative amount of ADA and XO gene transcripts in tissues and C6 cells.
Spec (examine) Negative_regulation (amount) of ADA
6) Confidence 0.43 Published 2007 Journal Acta Pharmacol. Sin. Section Body Doc Link 17640470 Disease Relevance 0 Pain Relevance 0
Unilateral transections of the stria medullaris caused substantial depletions of ADA-immunoreactivity and reduced enzymatically determined ADA activity by up to 80% in the medial habenula on the lesioned compared with the contralateral control side.
Negative_regulation (depletions) of ADA-immunoreactivity in medial
7) Confidence 0.43 Published 1988 Journal Brain Res. Section Abstract Doc Link 3046711 Disease Relevance 0 Pain Relevance 0.28
Dipyridamole and hydroxy-nitro-benzylthioguanosine (inhibitors of adenosine transport) and erythro-6-amino-9-(2-hydroxy-3-nonyl)adenine (EHNA, an inhibitor of adenosine deaminase), potentiated the depression by adenosine of the response to muscarine, and the hyperpolarization to adenosine respectively.
Negative_regulation (inhibitor) of adenosine deaminase associated with adenocard and depression
8) Confidence 0.42 Published 1993 Journal J Auton Pharmacol Section Abstract Doc Link 8514824 Disease Relevance 0.29 Pain Relevance 0.77
Kinetic and structural analysis of the inhibition of adenosine deaminase by acetaminophen.
Negative_regulation (inhibition) of adenosine deaminase associated with paracetamol and adenocard
9) Confidence 0.41 Published 2004 Journal J Enzyme Inhib Med Chem Section Title Doc Link 15202496 Disease Relevance 0 Pain Relevance 0.55
The present study examined the spinal antinociceptive effects of adenosine analogs and inhibitors of adenosine kinase and adenosine deaminase in the carrageenan-induced thermal hyperalgesia model in the rat.
Negative_regulation (inhibitors) of adenosine deaminase in spinal associated with adenocard, thermal hyperalgesia and antinociceptive
10) Confidence 0.39 Published 1998 Journal Pain Section Abstract Doc Link 9520238 Disease Relevance 0.53 Pain Relevance 0.86
Unilateral transections of the stria medullaris caused substantial depletions of ADA-immunoreactivity and reduced enzymatically determined ADA activity by up to 80% in the medial habenula on the lesioned compared with the contralateral control side.
Negative_regulation (reduced) of ADA in medial
11) Confidence 0.38 Published 1988 Journal Brain Res. Section Abstract Doc Link 3046711 Disease Relevance 0 Pain Relevance 0.28
Unilateral transections of the stria medullaris caused substantial depletions of ADA-immunoreactivity and reduced enzymatically determined ADA activity by up to 80% in the medial habenula on the lesioned compared with the contralateral control side.
Negative_regulation (depletions) of ADA in medial
12) Confidence 0.38 Published 1988 Journal Brain Res. Section Abstract Doc Link 3046711 Disease Relevance 0 Pain Relevance 0.29
Spinal administration of an adenosine kinase inhibitor, alone or in combination with an adenosine deaminase inhibitor, produces antinociception in inflammatory pain tests.
Negative_regulation (inhibitor) of adenosine deaminase in Spinal associated with antinociception, adenocard and ipn
13) Confidence 0.32 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10611432 Disease Relevance 0.45 Pain Relevance 0.75
No analgesia was seen following injection of 2'-deoxycoformycin (dCF; an adenosine deaminase inhibitor; 100-300 nmol).
Negative_regulation (inhibitor) of adenosine deaminase associated with adenocard and analgesia
14) Confidence 0.29 Published 1998 Journal Pain Section Abstract Doc Link 9520238 Disease Relevance 0.49 Pain Relevance 1.63
Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test.
Negative_regulation (inhibitor) of adenosine deaminase associated with pain, adenocard and antinociceptive
15) Confidence 0.26 Published 1998 Journal Pain Section Title Doc Link 9514563 Disease Relevance 0.09 Pain Relevance 0.86
Treatment with PEG-ADA was begun, the biochemical markers of ADA deficiency normalized, and his clinical progress was very good without significant infections.
Negative_regulation (deficiency) of ADA associated with infection
16) Confidence 0.22 Published 2005 Journal Pediatrics Section Abstract Doc Link 16263974 Disease Relevance 0.86 Pain Relevance 0.20
This study examined the ability of an adenosine kinase inhibitor (5'-amino-5'-deoxyadenosine; NH2dAD), an adenosine deaminase inhibitor (2'-deoxycoformycin), and combinations of these agents to produce a peripheral modulation of the pain signal in the low concentration formalin model.
Negative_regulation (inhibitor) of adenosine deaminase associated with pain, adenocard and eae
17) Confidence 0.19 Published 1998 Journal Pain Section Abstract Doc Link 9514563 Disease Relevance 0.10 Pain Relevance 0.45
Modulation of adenosine release from rat spinal cord by adenosine deaminase and adenosine kinase inhibitors.
Negative_regulation (inhibitors) of adenosine deaminase in spinal cord associated with adenocard and spinal cord
18) Confidence 0.14 Published 1995 Journal Brain Res. Section Title Doc Link 8616636 Disease Relevance 0.10 Pain Relevance 1.06
When 8-phenyltheophylline was present throughout superfusion the effects of both R-E 244 and exogenous adenosine deaminase were abolished.
Negative_regulation (abolished) of exogenous adenosine deaminase associated with adenocard
19) Confidence 0.07 Published 1985 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2984005 Disease Relevance 0 Pain Relevance 0.86
Inhibitors of adenosine kinase, but not adenosine deaminase, produce antinociception when administered spinally.
Negative_regulation (Inhibitors) of adenosine deaminase associated with antinociception and adenocard
20) Confidence 0.06 Published 1996 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8832217 Disease Relevance 0 Pain Relevance 0.65

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox