INT328058

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Context Info
Confidence 0.29
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 4.29
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4) cytoskeleton (FAAH)
cytoplasm (FAAH)
Anatomy Link Frequency
Sertoli cells 2
epithelial cells 1
PC-3 1
IL4 (Homo sapiens)
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 24 100.00 Very High Very High Very High
palliative 6 81.16 Quite High
dexamethasone 6 80.88 Quite High
Endocannabinoid 108 64.56 Quite High
Cannabinoid 54 24.44 Low Low
Hippocampus 18 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Immobilon 6 5.00 Very Low Very Low Very Low
Versed 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 306 99.38 Very High Very High Very High
Cancer 462 99.12 Very High Very High Very High
Teratocarcinoma 12 97.04 Very High Very High Very High
Disease 156 85.56 High High
Carcinoma 6 83.48 Quite High
Apoptosis 42 81.84 Quite High
Malignant Neoplastic Disease 72 60.84 Quite High
Overactive Bladder 6 55.36 Quite High
Glioma 12 18.68 Low Low
Glioblastoma 6 13.68 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We could confirm that tumour epithelial cells express IL-4 receptors, in line with previous studies using both tumour tissue and cultured cells [29], [36], and could demonstrate that IL-4 increases FAAH activity in a PC-3 and R3327 AT1 prostate cancer cells as well as in P19 teratocarcinoma cells, indicating it to be a rather general effect of this cytokine.
IL-4 Positive_regulation (increases) of FAAH in PC-3 associated with teratocarcinoma, cancer, prostate cancer and cytokine
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.80 Pain Relevance 0.11
(which decrease FAAH activity in lymphocytes), progesterone, leptin, the TH2 cytokines IL-4 and IL-10 (which increase FAAH activity and FAAH protein content in lymphocytes), and follicle stimulating hormone (which increases FAAH activity in Sertoli cells) [26], [65], [66].
TH2 cytokines IL-4 Positive_regulation (increase) of FAAH in Sertoli cells associated with cytokine
2) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.70 Pain Relevance 0.13
Interleukin-4 (IL-4) stimulation of FAAH activity in cultured cancer cells
IL-4 Positive_regulation (stimulation) of FAAH associated with cancer
3) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.31 Pain Relevance 0.04
Interleukin-4 (IL-4) stimulation of FAAH activity in cultured cancer cells
Interleukin-4 Positive_regulation (stimulation) of FAAH associated with cancer
4) Confidence 0.19 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.31 Pain Relevance 0.04
Interleukin-4 (IL-4) receptor IR was found on tumour epithelial cells and incubation of prostate cancer PC-3 and R3327 AT1 cells with IL-4 increased their FAAH activity.


IL-4 Positive_regulation (increased) of FAAH in epithelial cells associated with cancer and prostate cancer
5) Confidence 0.17 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2924377 Disease Relevance 1.38 Pain Relevance 0.08
(which decrease FAAH activity in lymphocytes), progesterone, leptin, the TH2 cytokines IL-4 and IL-10 (which increase FAAH activity and FAAH protein content in lymphocytes), and follicle stimulating hormone (which increases FAAH activity in Sertoli cells) [26], [65], [66].
TH2 cytokines IL-4 Positive_regulation (increases) of FAAH in Sertoli cells associated with cytokine
6) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.79 Pain Relevance 0.13

General Comments

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