INT328059

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Context Info
Confidence 0.25
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 4.57
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4) cytoskeleton (FAAH)
cytoplasm (FAAH)
Anatomy Link Frequency
lymphocytes 3
IL4 (Homo sapiens)
FAAH (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 16 100.00 Very High Very High Very High
Endocannabinoid 72 87.60 High High
Cannabinoid 36 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Immobilon 4 5.00 Very Low Very Low Very Low
Versed 4 5.00 Very Low Very Low Very Low
antagonist 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 204 100.00 Very High Very High Very High
Cancer 308 98.24 Very High Very High Very High
Malignant Neoplastic Disease 48 89.64 High High
Teratocarcinoma 8 50.48 Quite High
Disease 104 50.00 Quite Low
Apoptosis 28 26.28 Quite Low
Death 28 5.00 Very Low Very Low Very Low
Metastasis 24 5.00 Very Low Very Low Very Low
Pancreatic Cancer 12 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The TH2 cytokine interleukin-4 (IL-4), which has been reported to regulate FAAH and CB1 receptors in lymphocytes and Jurkat cells [26]–[28], is involved the pathogenesis of several cancer types, including prostate cancer (see [29]–[35]).
IL-4 Regulation (regulate) of FAAH in lymphocytes associated with cancer, prostate cancer and cytokine
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 1.26 Pain Relevance 0.05
The present data motivate studies designed to determine how IL-4 regulates FAAH in prostate cancer cells compared to lymphocytes, whether stromal IL-4 immunoreactivity (and/or expression of IL-4 receptors in the tumour epithelia) correlates with tumour epithelial FAAH-IR in prostate cancer tissue, and which other components of the tumour microenvironment are potential regulators of the endocannabinoid system.



IL-4 Regulation (regulates) of FAAH in lymphocytes associated with endocannabinoid, cancer and prostate cancer
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 0.95 Pain Relevance 0.07
The TH2 cytokine interleukin-4 (IL-4), which has been reported to regulate FAAH and CB1 receptors in lymphocytes and Jurkat cells [26]–[28], is involved the pathogenesis of several cancer types, including prostate cancer (see [29]–[35]).
TH2 cytokine interleukin-4 Regulation (regulate) of FAAH in lymphocytes associated with cancer, prostate cancer and cytokine
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 1.27 Pain Relevance 0.05
FAAH activity in prostate cancer cell lines is affected by interleukin-4
interleukin-4 Regulation (affected) of FAAH associated with prostate cancer
4) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2924377 Disease Relevance 1.10 Pain Relevance 0.04

General Comments

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