INT328200

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Context Info
Confidence 0.01
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.55
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Pitrm1) nucleus (Pitrm1) cytoplasm (Pitrm1)
Anatomy Link Frequency
immune system 1
Pitrm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 3 98.34 Very High Very High Very High
tolerance 1 45.40 Quite Low
diabetic neuropathy 1 37.40 Quite Low
Bile 1 22.16 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
pruritus 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
analgesia 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Photosensitivity Disorders 2 92.96 High High
Eye Disease 1 65.68 Quite High
Reprotox - General 1 1 64.04 Quite High
Lifespan 1 63.12 Quite High
Aging 3 61.52 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 59.28 Quite High
Diabetes Mellitus 13 53.72 Quite High
Hyperglycemia 1 49.72 Quite Low
Disease 1 48.00 Quite Low
Impaired Glucose Tolerance 1 45.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alcoholic and aqueous extracts of T. cordifolia are reported to have beneficial effects on the immune system[8187] and have been tested successfully for their immunomodulatory activity.[97-103] The degradation of proteins due to photosensitization as assessed by Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) was effectively reduced by simultaneous treatment with G1-4A/PPI (partially purified immunomodulator) from T. cordifolia during photosensitization.[104] The novel (1,4)-alpha-D-glucan derived from the plant activates the immune system through the activation of macrophages via TLR6 signaling, NFkappaB translocation and cytokine production.[32105] Tinospora cordifolia differentially regulate elevation of cytokines as evidenced by the increased production of antiangiogenic agents IL-2 and tissue inhibitor of metalloprotease-1 (TIMP-1) in the B16F10-injected, extract-treated animals.
Negative_regulation (inhibitor) of metalloprotease-1 in immune system associated with photosensitivity disorders and cytokine
1) Confidence 0.01 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2924974 Disease Relevance 0.55 Pain Relevance 0.14

General Comments

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