INT328215

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Context Info
Confidence 0.20
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.35
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
cartilage 1
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 30 99.00 Very High Very High Very High
Inflammation 14 94.12 High High
Arthritis 33 84.08 Quite High
metalloproteinase 7 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 30 99.00 Very High Very High Very High
Severe Combined Immunodeficiency 14 97.36 Very High Very High Very High
INFLAMMATION 14 94.12 High High
Arthritis 34 84.08 Quite High
Disease 5 56.68 Quite High
Frailty 2 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Arthralgia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It has been shown that inhibition of MMP-1 by ribozymes has a protective effect on cartilage erosion in the SCID mouse co-implantation model.14 Both MMP-1 and MMP-13 contribute to the process of cartilage destruction in RA and can therefore be targeted for treatment.
MMP-1 Neg (inhibition) Binding (inhibition) of in cartilage associated with severe combined immunodeficiency and rheumatoid arthritis
1) Confidence 0.20 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 1.35 Pain Relevance 0.45

General Comments

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