INT328219

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Context Info
Confidence 0.31
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.65
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp1a) extracellular region (Mmp1a) proteinaceous extracellular matrix (Mmp1a)
Anatomy Link Frequency
joints 1
Mmp1a (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 7 97.92 Very High Very High Very High
Inflammation 14 94.62 High High
rheumatoid arthritis 30 93.10 High High
Arthritis 33 27.36 Quite Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arthritis 34 100.00 Very High Very High Very High
INFLAMMATION 14 94.62 High High
Disease 5 93.80 High High
Rheumatoid Arthritis 30 93.10 High High
Severe Combined Immunodeficiency 14 32.24 Quite Low
Frailty 2 5.00 Very Low Very Low Very Low
Immunization 1 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Syndrome 1 5.00 Very Low Very Low Very Low
Arthralgia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterised by persistent inflammatory reactions in the joints resulting in a progressive articular destruction associated with the loss of joint function and disability.1 Matrix metalloproteinases (MMPs) are a family of secreted or transmembrane zinc-dependent endoproteinases that are responsible for the degradation of cartilage in arthritides.2 3 MMP-1 and MMP-13 are powerful collagenolytic enzymes, cleaving type II collagen.
Protein_catabolism (degradation) of MMP-1 in joints associated with inflammation, metalloproteinase, rheumatoid arthritis, disease and arthritis
1) Confidence 0.31 Published 2010 Journal Annals of the Rheumatic Diseases Section Body Doc Link PMC2925150 Disease Relevance 0.65 Pain Relevance 0.33

General Comments

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