INT328227

Context Info Confidence 0.45 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.67 Pain Relevance 0.28

endoplasmic reticulum (Hmox1) enzyme binding (Hmox1) signal transducer activity (Hmox1) cytosol (Hmox1) signal transduction (Hmox1) cell death (Hmox1)

Hmox1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 2 82.52 cerebral cortex 1 78.16 Hippocampus 1 76.56 cINOD 35 71.84 Inflammation 37 50.00 ischemia 1 35.16 Glutamate 5 27.52 chemokine 1 16.72 cytokine 8 5.00 Central nervous system 7 5.00

Disease Link Frequency Relevance Heat Stress 7 97.44 Disease 125 91.64 Injury 5 89.20 Amyloid Plaque 3 72.64 INFLAMMATION 49 50.00 Apoptosis 1 49.52 Death 2 38.28 Cv Unclassified Under Development 2 35.16 Targeted Disruption 3 29.60 Alzheimer's Dementia 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Though glia cells can also exhibit antioxidative functions by releasing hemeoxygenase-1 (HO-1) triggered by accumulation of 3-hydroxyanthralinic acid (3-HAA), a down-stream product of the tryptophan metabolism.

Positive_regulation (triggered) of Localization (releasing) of hemeoxygenase-1

1) Confidence 0.45 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2925207 Disease Relevance 0.67 Pain Relevance 0.28

General Comments

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