INT32826

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Context Info
Confidence 0.45
First Reported 1985
Last Reported 2011
Negated 8
Speculated 3
Reported most in Body
Documents 52
Total Number 57
Disease Relevance 10.34
Pain Relevance 26.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
hippocampus 4
synapses 4
pyramidal cells 2
ACC neurons 2
dorsal horn 2
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 2135 100.00 Very High Very High Very High
amygdala 809 100.00 Very High Very High Very High
depression 651 100.00 Very High Very High Very High
qutenza 316 100.00 Very High Very High Very High
Hippocampus 304 100.00 Very High Very High Very High
Glutamate receptor 33 99.88 Very High Very High Very High
nMDA receptor 343 99.82 Very High Very High Very High
agonist 217 99.76 Very High Very High Very High
nMDA receptor antagonist 53 99.76 Very High Very High Very High
Anterior cingulate cortex 207 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 653 100.00 Very High Very High Very High
Targeted Disruption 280 99.48 Very High Very High Very High
Anaerobic Bacterial Infections 36 99.40 Very High Very High Very High
Pain 84 98.96 Very High Very High Very High
Anxiety Disorder 145 98.54 Very High Very High Very High
Drug Dependence 13 95.96 Very High Very High Very High
Disease 163 85.92 High High
Nervous System Injury 11 85.28 High High
Stress 71 84.92 Quite High
Hypotension 2 80.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HFS paradigm has been chosen since theta burst stimulation did not produce consistent and reliable induction of LA-LTP.


Positive_regulation (induction) of Neg (not) Gene_expression (produce) of LTP associated with long-term potentiation and amygdala
1) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.35
However, the suppressive effect of capsaicin on LA-LTP was also present in coronal slices derived from juvenile mice (control: 120.5±3.2% [n?
Positive_regulation (-) of Gene_expression (effect) of LTP in juvenile associated with qutenza, long-term potentiation and amygdala
2) Confidence 0.45 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.95
It appears that postsynaptic firing of action potentials during repetitive stimulation is necessary to produce LTP.
Positive_regulation (necessary) of Gene_expression (produce) of LTP associated with action potential and long-term potentiation
3) Confidence 0.40 Published 1985 Journal Brain Res. Section Abstract Doc Link 2985203 Disease Relevance 0 Pain Relevance 0.51
While the induction of LTP in general requires activation of postsynaptic glutamate receptors, the expression of LTP can be mediated by postsynaptic mechanisms and/or presynaptic enhancement of glutamate release.
Positive_regulation (mediated) of Gene_expression (expression) of LTP associated with glutamate, glutamate receptor and long-term potentiation
4) Confidence 0.39 Published 2009 Journal Mol. Neurobiol. Section Abstract Doc Link 19821080 Disease Relevance 0.41 Pain Relevance 0.86
To examine whether capsaicin-induced suppression of LTP is mediated by TRPV1 receptors, we analyzed the effects of capsaicin in the presence of capsazepine (CZ), a TRPV1 receptor antagonist.
Spec (whether) Positive_regulation (induced) of Gene_expression (suppression) of LTP associated with qutenza, antagonist and long-term potentiation
5) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.51
The AM251-induced LTP suppression in the hippocampus was interpreted by the action of AM251 over GABAergic interneurons that (indirectly) modulate the glutamatergic, LTP-bearing pyramidal cells.
Positive_regulation (induced) of Gene_expression (suppression) of LTP in pyramidal cells associated with pyramidal cell, gabaergic, hippocampus and long-term potentiation
6) Confidence 0.39 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 1.19
LTP produced by nerve transection could not be further potentiated by electrical tetanic stimulation, while LTP induced by single electrical tetanic stimulation could be further potentiated by transection of the sciatic nerve.
Neg (not) Positive_regulation (potentiated) of Gene_expression (produced) of LTP in nerve associated with sciatic nerve and long-term potentiation
7) Confidence 0.38 Published 2004 Journal Sheng Li Xue Bao Section Abstract Doc Link 15497039 Disease Relevance 0.36 Pain Relevance 1.54
Since our immunohistochemical study revealed that translocation of CaMKIV into the nuclei was markedly larger in the CaMKIV transgenic mice than in the wild-type mice, protein synthesis would be readily caused by LTP induction in the CaMKIV transgenic mice.
Positive_regulation (caused) of Gene_expression (induction) of LTP associated with targeted disruption and long-term potentiation
8) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.48 Pain Relevance 0.54
This result also suggests that paired training can induce protein synthesis by activating translation immediately after LTP introduction in the ACC neurons of CaMKIV transgenic mice.
Positive_regulation (activating) of Gene_expression (introduction) of LTP in ACC neurons associated with targeted disruption, long-term potentiation and anterior cingulate cortex
9) Confidence 0.37 Published 2010 Journal Mol Brain Section Body Doc Link PMC2949850 Disease Relevance 0.36 Pain Relevance 0.35
Nonetheless, collectively these data indicate that somatic population spikes are unlikely to be principal contributors to increased proximal fEPSPs after LTP induction.
Positive_regulation (increased) of Gene_expression (induction) of LTP in proximal associated with long-term potentiation
10) Confidence 0.35 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.07 Pain Relevance 0.48
The expression of classical MF LTP is due to an increase in transmitter release and both pharmacological and genetic analyses indicate that a rise in presynaptic cAMP is a critical component [20], [21].
Positive_regulation (increase) of Spec (analyses) Gene_expression (expression) of MF LTP associated with long-term potentiation
11) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2848597 Disease Relevance 0 Pain Relevance 0.37
It has been reported that an alteration in AMPA receptor channel kinetics could underlie the expression of LTP [26].
Positive_regulation (underlie) of Gene_expression (expression) of LTP associated with long-term potentiation
12) Confidence 0.34 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.39
All of these may lead to substantial rise in postsynaptic [Ca2+]i, which is essential for LTP induction.
Positive_regulation (essential) of Gene_expression (induction) of LTP associated with long-term potentiation
13) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.27 Pain Relevance 1.45
Signal transduction of LTP involves Ca2+-dependent pathways including PKC, CaMKII, PKA, NOS and members of MAPK including ERK [6,8,13-15,29].
Positive_regulation (transduction) of Gene_expression (transduction) of LTP associated with kinase c and long-term potentiation
14) Confidence 0.32 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704201 Disease Relevance 0.21 Pain Relevance 1.33
Rescue of Hippocampal LTP in Neurabin KO Mice by Pre-conditioning with LTD Induction
Positive_regulation (Rescue) of Gene_expression (Rescue) of LTP associated with targeted disruption, depression and long-term potentiation
15) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2169299 Disease Relevance 0.66 Pain Relevance 0.24
Studies have also shown that blocking SK channels facilitates the induction of LTP (Behnisch and Reymann, 1998; Stackman et al., 2002) and that genetic overexpression of SK2 channels inhibits LTP induction and hippocampal-dependent learning (Hammond et al., 2006).
Positive_regulation (overexpression) of Gene_expression (overexpression) of LTP associated with long-term potentiation
16) Confidence 0.29 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.53
The muscarinic M1 receptor allosteric agonist 77-LH-28-1 facilitates LTP induction ?
Positive_regulation (facilitates) of Gene_expression (induction) of LTP associated with agonist and long-term potentiation
17) Confidence 0.29 Published 2010 Journal Neuron Section Abstract Doc Link PMC3003154 Disease Relevance 0.06 Pain Relevance 0.45
However, there was no correlation between the amount of LTP induced and the amplitude of the mAChR-mediated EPSP during LTP induction (data not shown).


Positive_regulation (mediated) of Gene_expression (induction) of LTP associated with long-term potentiation
18) Confidence 0.29 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.29
However, there was no correlation between the amount of LTP induced and the amplitude of the mAChR-mediated EPSP during LTP induction (data not shown).


Positive_regulation (induced) of Gene_expression (amplitude) of LTP associated with long-term potentiation
19) Confidence 0.29 Published 2010 Journal Neuron Section Body Doc Link PMC3003154 Disease Relevance 0 Pain Relevance 0.29
Inhibition of SK channels enhances NMDA receptor opening during LTP induction ?
Positive_regulation (during) of Gene_expression (induction) of LTP associated with nmda receptor and long-term potentiation
20) Confidence 0.29 Published 2010 Journal Neuron Section Abstract Doc Link PMC3003154 Disease Relevance 0.05 Pain Relevance 0.52

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