INT328277

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Context Info
Confidence 0.36
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 2 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 4 97.60 Very High Very High Very High
Leukemia 2 96.36 Very High Very High Very High
Solid Tumor 10 94.64 High High
Breast Cancer 98 93.12 High High
Cancer 26 88.36 High High
Lung Cancer 4 77.52 Quite High
Glioblastoma 12 75.84 Quite High
Ovarian Cancer 2 70.04 Quite High
Necrosis 2 68.40 Quite High
Apoptosis 38 68.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Besides abl and bcr-abl, imatinib also inhibits the activation of PDGFR ?
Negative_regulation (inhibits) of Positive_regulation (activation) of PDGFR
1) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 1.03 Pain Relevance 0
In our study we could demonstrate that imatinib is able to inhibit the autocrine and paracrine mediated activation of the PDGFR ?
Negative_regulation (inhibit) of Positive_regulation (activation) of PDGFR
2) Confidence 0.32 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2925350 Disease Relevance 0.61 Pain Relevance 0

General Comments

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