INT328309

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GH1) extracellular region (GH1)
GHS (Homo sapiens)
GH1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 68 96.00 Very High Very High Very High
Somatostatin 28 93.52 High High
cytokine 16 59.92 Quite High
antagonist 76 40.08 Quite Low
Eae 12 37.24 Quite Low
Inflammation 40 28.56 Quite Low
tolerance 16 18.12 Low Low
medulla 16 5.00 Very Low Very Low Very Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
vagus nerve 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 60 99.84 Very High Very High Very High
Targeted Disruption 68 87.44 High High
Appetite Loss 52 84.52 Quite High
Body Weight 16 75.92 Quite High
Growth Problems 20 69.76 Quite High
Repression 24 68.56 Quite High
Hypotension 12 67.76 Quite High
Aging 12 61.60 Quite High
Apoptosis 32 60.92 Quite High
Hypoglycemia 16 54.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonacylated synthetic GHS can stimulate GH secretion in occasional models [222–224].
GHS Positive_regulation (stimulate) of Localization (secretion) of GH
1) Confidence 0.04 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.41 Pain Relevance 0.08
In humans, pharmacologic or surgical interruption of vagal cholinergic traffic lowers ghrelin concentrations and blunts appetitive stimulation but does not block GHS-induced GH release [336, 431, 433].

5.2.

GHS Positive_regulation (induced) of Localization (release) of GH
2) Confidence 0.03 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.14 Pain Relevance 0.05
Depending upon chemical structure and dose, synthetic GHS can stimulate GH secretion after intranasal, oral, s.c., or i.v. administration [4, 65, 250, 272, 282, 283].
GHS Positive_regulation (stimulate) of Localization (secretion) of GH
3) Confidence 0.03 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.23 Pain Relevance 0
Likewise, why age and obesity impair GHS-induced secretion of GH but not of ACTH and prolactin is not known [113, 281].
GHS Positive_regulation (induced) of Localization (secretion) of GH associated with obesity
4) Confidence 0.03 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.21 Pain Relevance 0

General Comments

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