INT328336

Context Info Confidence 0.02 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.43 Pain Relevance 0

mitochondrion (MCCC2) small molecule metabolic process (MCCC2) cellular nitrogen compound metabolic process (MCCC2) ligase activity (MCCC2)

Anatomy Link Frequency fat 1 MCCC2 (Homo sapiens)

Pain Link Frequency Relevance Heat medulla 4 14.24 antagonist 19 5.00 agonist 17 5.00 Inflammation 10 5.00 Somatostatin 7 5.00 cytokine 4 5.00 tolerance 4 5.00 Neuropeptide 3 5.00 vagus nerve 3 5.00 Eae 3 5.00

Disease Link Frequency Relevance Heat Repression 6 96.88 Hypertrophy 2 86.24 Renal Failure 4 75.00 Cancer 6 63.16 Body Weight 4 60.40 Carcinoma 3 53.00 Reprotox - General 1 1 21.12 Apoptosis 8 18.96 Obesity 15 17.72 Targeted Disruption 17 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Relevant mechanisms embrace repression of insulin-sensitizing genes, such as adiponectin, and induction of adipocyte leptin and peroxisome-proliferating activator receptor- (PPAR-) gamma genes; stimulation of endothelial lipoprotein lipase, adipocyte fatty acid synthase, acetyl CoA carboxylase, and fat-cell glucose uptake; and inhibition of fat oxidation via rate-limiting carnitine-palmitoyl transferase [167, 171, 172, 191, 554, 555].

Positive_regulation (stimulation) of CoA carboxylase in fat associated with repression

1) Confidence 0.02 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.43 Pain Relevance 0

General Comments

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