INT328374

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Context Info
Confidence 0.13
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.26
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (GHRH, Ghrl) extracellular region (GHRH, Ghrl) cytoplasm (Ghrl)
cell-cell signaling (GHRH)
Anatomy Link Frequency
brain 1
pituitary 1
GHRH (Homo sapiens)
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 14 91.60 High High
antagonist 38 88.88 High High
adenocard 2 15.04 Low Low
agonist 34 5.00 Very Low Very Low Very Low
Inflammation 20 5.00 Very Low Very Low Very Low
medulla 8 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
tolerance 8 5.00 Very Low Very Low Very Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
vagus nerve 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 6 69.44 Quite High
Growth Problems 10 68.24 Quite High
Appetite Loss 26 65.68 Quite High
Pancreatic Cancer 2 35.68 Quite Low
Aplasia 2 33.44 Quite Low
Targeted Disruption 34 5.00 Very Low Very Low Very Low
Obesity 30 5.00 Very Low Very Low Very Low
INFLAMMATION 24 5.00 Very Low Very Low Very Low
Stress 20 5.00 Very Low Very Low Very Low
Apoptosis 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although GHRH can induce the pituitary ghrelin and GHS-R1a genes [42], the physiological impact of this potentially amplifying mechanism is not known.
GHRH Positive_regulation (induce) of ghrelin in pituitary
1) Confidence 0.13 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.13 Pain Relevance 0.04
This model does not include pituitary ghrelin, which is downregulated by excessive thyroxine, glucocorticoid, or brain-GH feedback and upregulated by GHRH [42].
GHRH Positive_regulation (upregulated) of ghrelin in brain
2) Confidence 0.11 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.13 Pain Relevance 0.09

General Comments

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