INT328382

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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.08
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl, INS) extracellular region (Ghrl, INS) small molecule metabolic process (INS)
carbohydrate metabolic process (INS) cell-cell signaling (INS) cytoplasm (Ghrl)
Ghrl (Rattus norvegicus)
INS (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 19 97.56 Very High Very High Very High
tolerance 4 97.08 Very High Very High Very High
agonist 17 96.60 Very High Very High Very High
Somatostatin 7 45.52 Quite Low
medulla 4 36.00 Quite Low
Inflammation 10 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
vagus nerve 3 5.00 Very Low Very Low Very Low
Eae 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperinsulinism 4 100.00 Very High Very High Very High
Targeted Disruption 17 99.70 Very High Very High Very High
Impaired Glucose Tolerance 5 97.08 Very High Very High Very High
Obesity 15 83.92 Quite High
Insulin Resistance 5 68.76 Quite High
Syndrome 3 67.04 Quite High
Metabolic Syndrome 3 62.72 Quite High
Diabetes Mellitus 5 60.32 Quite High
Hypotension 3 34.48 Quite Low
Increased Venous Pressure Under Development 4 19.12 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, in knockout ghrelin mice, increased constitutive ghrelin-receptor activity may result in increased insulin secretion, which would be susceptible to inhibition by a GHS receptor antagonist with inverse agonist activity.
Positive_regulation (increased) of ghrelin Spec (may) Positive_regulation (result) of Localization (secretion) of insulin associated with targeted disruption, antagonist, agonist and hyperinsulinism
1) Confidence 0.03 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 1.08 Pain Relevance 0.23

General Comments

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