INT328385

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Context Info
Confidence 0.15
First Reported 2010
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.89
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrl) extracellular region (Ghrl) cytoplasm (Ghrl)
GHS (Homo sapiens)
Ghrl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Eae 12 98.72 Very High Very High Very High
agonist 68 93.64 High High
Potency 4 93.48 High High
cytokine 16 87.84 High High
tolerance 16 79.60 Quite High
antagonist 76 40.36 Quite Low
Inflammation 40 5.00 Very Low Very Low Very Low
Somatostatin 28 5.00 Very Low Very Low Very Low
medulla 16 5.00 Very Low Very Low Very Low
Neuropeptide 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 24 96.92 Very High Very High Very High
Body Weight 16 90.24 High High
Targeted Disruption 68 87.28 High High
Apoptosis 32 85.84 High High
Diabetes Mellitus 20 85.36 High High
Hypoglycemia 16 81.68 Quite High
Impaired Glucose Tolerance 20 79.60 Quite High
Obesity 60 78.36 Quite High
Hypotension 12 72.32 Quite High
Growth Problems 20 55.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GHS receptor type 1b arises from a nonspliced transcript, whose product does not bind acylghrelin or confer known bioactivity [5, 187].
GHS Neg (not) Binding (bind) of ghrelin
1) Confidence 0.15 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.93 Pain Relevance 0.19
In addition, scientists at Merck laboratories demonstrated that Ser2 mono-octanoylated ghrelin 1–28 binds to GHS-R1a in vitro.
GHS Binding (binds) of ghrelin
2) Confidence 0.12 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.09 Pain Relevance 0.05
There is an additional possibility that partial overlap of ghrelin-binding properties of GHS-R1a, GOAT, and ERAT could contribute to differences and similarities between ghrelin and GHS mimetics as well as competition between full and partial GHS-R1a agonists [653].
GHS Binding (binding) of ghrelin associated with agonist
3) Confidence 0.09 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0 Pain Relevance 0.05
Moreover, multiple biological effects have been reported for desacyl-ghrelin, which essentially does not bind GHS-R1a.
GHS Neg (not) Binding (bind) of ghrelin
4) Confidence 0.07 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.87 Pain Relevance 0.16

General Comments

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