INT328410

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Context Info
Confidence 0.07
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.31
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

enzyme binding (Nlrp1a, Snca) nucleus (Nlrp1a, Snca) mitochondrion (Snca)
histone binding (Snca) cytoplasm (Snca) cytosol (Snca)
Anatomy Link Frequency
striatum 1
cortex 1
Nlrp1a (Mus musculus)
Snca (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 12 99.88 Very High Very High Very High
Substantia nigra 40 77.44 Quite High
Paracetamol 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 52 98.32 Very High Very High Very High
Stress 24 57.52 Quite High
Disease 56 49.48 Quite Low
Toxicity 16 5.00 Very Low Very Low Very Low
Parkinson's Disease 8 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Body Weight 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NAC significantly reduced the amount of overexpressed human SNCA protein in the cortex and striatum of PDGFb-SNCA transgenic mice (Fig. 2E–2H).
NAC Negative_regulation (reduced) of SNCA protein in striatum associated with targeted disruption
1) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.16 Pain Relevance 0.15
NAC significantly reduced the amount of overexpressed human SNCA protein in the cortex and striatum of PDGFb-SNCA transgenic mice (Fig. 2E–2H).
NAC Negative_regulation (reduced) of SNCA protein in cortex associated with targeted disruption
2) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925900 Disease Relevance 0.16 Pain Relevance 0.15

General Comments

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