INT328437

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.60
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRB4, VEGFA) extracellular space (VEGFA) growth (VEGFA)
proteinaceous extracellular matrix (VEGFA) molecular_function (PRB4) cytoplasm (VEGFA)
Anatomy Link Frequency
HT-1080 4
PRB4 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 97.08 Very High Very High Very High
imagery 2 93.80 High High
Potency 4 58.60 Quite High
aspirin 4 42.00 Quite Low
Inflammation 2 30.44 Quite Low
addiction 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 26 95.00 High High
Fibrosarcoma 16 85.04 High High
Hypersensitivity 2 31.48 Quite Low
INFLAMMATION 2 30.44 Quite Low
Sarcoma 2 5.92 Low Low
Thrombosis 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Solid Tumor 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that PO inhibits bFGF-induced angiogenesis in HUVECs and decreased the levels of PI3K, phospho-AKT and VEGF in HT-1080 cells.



PO Negative_regulation (decreased) of Gene_expression (levels) of VEGF in HT-1080
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2925949 Disease Relevance 0.29 Pain Relevance 0.05
We observed that PO inhibited extracellular production and intracellular expression of VEGF in HT-1080 cells.
PO Negative_regulation (inhibited) of Gene_expression (expression) of VEGF in HT-1080
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.32 Pain Relevance 0.08

General Comments

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