INT328439

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Context Info
Confidence 0.09
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.66
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (PRB4, VEGFA) extracellular space (VEGFA) growth (VEGFA)
proteinaceous extracellular matrix (VEGFA) molecular_function (PRB4) cytoplasm (VEGFA)
Anatomy Link Frequency
HT-1080 4
PRB4 (Homo sapiens)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 51.88 Quite High
Potency 4 13.40 Low Low
aspirin 4 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sarcoma 2 99.52 Very High Very High Very High
Fibrosarcoma 16 99.36 Very High Very High Very High
Cancer 26 91.80 High High
Disease 2 72.72 Quite High
Thrombosis 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Solid Tumor 2 5.00 Very Low Very Low Very Low
Death 2 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also showed that PO suppressed PI3K/AKT signaling and reduced VEGF secretion and expression fibrosarcoma HT-1080 cells, which is consistent with the current understanding of the role of VEGF/PI3K in angiogenesis.
PO Negative_regulation (reduced) of Localization (secretion) of VEGF in HT-1080 associated with fibrosarcoma
1) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.41 Pain Relevance 0
Similarly, we also showed that PO reduced the expression of PI3K, subsequently downregulated the phosphorylation of AKT, and VEGF secretion in HT-1080 sarcoma cells.
PO Negative_regulation (reduced) of Localization (secretion) of VEGF in HT-1080 associated with sarcoma
2) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.24 Pain Relevance 0.03

General Comments

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