INT328448

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Context Info
Confidence 0.21
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.84
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PIK3CD) signal transduction (PIK3CD) plasma membrane (PIK3CD)
Anatomy Link Frequency
HT-1080 2
PIK3CD (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 2 99.76 Very High Very High Very High
aspirin 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
IPN 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemorrhage 2 99.76 Very High Very High Very High
Thrombosis 2 99.16 Very High Very High Very High
Fibrosarcoma 16 94.72 High High
Cancer 26 91.52 High High
Death 2 12.64 Low Low
Sarcoma 2 5.00 Very Low Very Low Very Low
Hypoxia 2 5.00 Very Low Very Low Very Low
Solid Tumor 2 5.00 Very Low Very Low Very Low
Wound Healing 2 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PO downregulated the expression of VEGF and PI3K/AKT signaling in HT-1080 cells
Negative_regulation (downregulated) of Gene_expression (expression) of PI3K in HT-1080
1) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.47 Pain Relevance 0.05
As shown in Fig. 5C, PO at 12.5 µg/ml led to the decreased expression of PI3K and phosphorylation of its downstream target AKT.
Negative_regulation (decreased) of Gene_expression (expression) of PI3K
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2925949 Disease Relevance 0.37 Pain Relevance 0.03

General Comments

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