INT328507

Context Info Confidence 0.58 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.07 Pain Relevance 0

Pain Term Frequency Confidence Heat Migraine 4 5.00 Central nervous system 1 5.00 Clonidine 1 5.00 cocaine 1 5.00 antiepileptic Drug 7 5.00 anticonvulsant 2 5.00 Bioavailability 1 5.00 gABA 6 5.00 Dopamine 1 5.00 Substantia nigra 1 5.00

Disease Term Frequency Confidence Heat Breast Cancer 5 74.96 Toxicity 8 50.00 Apoptosis 15 40.04 Fibrosis 1 5.00 Hyperhomocysteinemia 5 5.00 Alopecia 3 5.00 Thrombocytopenia 6 5.00 Tremor 1 5.00 Abdominal Pain 1 5.00 Depression 7 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, it has been shown that valproic acid downregulates expression of proteins essential for chromatin maintenance: SMCs 1-6 (Structural Maintenance of chromatin 1 to 6), DNMT1 (DNA methyl transferase-1), and HP1 (Heterochromatin Protein-1) [25].

Gene_expression (expression) of SMCs 1-6

1) Confidence 0.58 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.