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Context Info
Confidence 0.03
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.79
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cdkn1a) nucleus (Cdkn1a) cell cycle (Cdkn1a)
kinase activity (Cdkn1a) cytoplasm (Cdkn1a)
Cdkn1a (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 1 71.16 Quite High
fibrosis 1 66.48 Quite High
carbamazepine 4 19.64 Low Low
Clonidine 1 18.92 Low Low
Buprenorphine 1 14.48 Low Low
addiction 6 8.08 Low Low
depression 9 5.00 Very Low Very Low Very Low
antiepileptic Drug 7 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Lamotrigine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myeloid Leukemia 8 100.00 Very High Very High Very High
Cancer 26 92.88 High High
INFLAMMATION 1 71.16 Quite High
Contracture 1 68.00 Quite High
Fibrosis 1 66.48 Quite High
Disease 24 55.84 Quite High
Muscular Dystrophy 1 54.24 Quite High
Apoptosis 15 52.56 Quite High
Toxicity 8 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 49.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VPA appears to induce an increase in the amount of p21WAF1 protein over 48 hours in AML cells, which is independent of p53 levels (whose expression is not modulated by VPA), but appears to be dependent on c-myc, whose mRNA and protein levels decrease in a dose-dependent manner during VPA treatment.
Regulation (dependent) of Positive_regulation (increase) of p21WAF1 associated with myeloid leukemia
1) Confidence 0.03 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 0.79 Pain Relevance 0.07

General Comments

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