INT328553

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Context Info
Confidence 0.49
First Reported 2010
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.03
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (SMN2) nucleoplasm (SMN2) cell death (SMN2)
mRNA processing (SMN2) RNA binding (SMN2) nucleus (SMN2)
SMN2 (Homo sapiens)
Pain Link Frequency Relevance Heat
carbamazepine 4 74.44 Quite High
Bioavailability 1 56.76 Quite High
depression 9 5.00 Very Low Very Low Very Low
antiepileptic Drug 7 5.00 Very Low Very Low Very Low
gABA 6 5.00 Very Low Very Low Very Low
Lamotrigine 6 5.00 Very Low Very Low Very Low
addiction 6 5.00 Very Low Very Low Very Low
Migraine 4 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
anticonvulsant 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 24 98.16 Very High Very High Very High
Spinal Muscular Atrophy 9 95.68 Very High Very High Very High
Neurodegenerative Disease 1 86.00 High High
Neurological Disease 6 84.44 Quite High
Coma 2 83.28 Quite High
Heart Rate Under Development 1 82.76 Quite High
Apoptosis 15 53.04 Quite High
Toxicity 8 50.00 Quite Low
Cancer 26 21.92 Low Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VPA is a promising candidate for Fl-SMN2-overexpression therapies, because it has been shown that it is able to increase both SMN transcript and protein levels in SMA patients.
Positive_regulation (overexpression) of Gene_expression (overexpression) of SMN2 associated with spinal muscular atrophy
1) Confidence 0.49 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2926634 Disease Relevance 1.03 Pain Relevance 0.07

General Comments

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