INT3286

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Context Info
Confidence 0.69
First Reported 1976
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 90
Total Number 91
Disease Relevance 45.08
Pain Relevance 28.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

biosynthetic process (Gpt) cellular_component (Gpt) biological_process (Gpt)
cytoplasm (Gpt)
Anatomy Link Frequency
liver 15
blood 9
plasma 4
PSP 1
urine 1
Gpt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 88 100.00 Very High Very High Very High
cytokine 24 100.00 Very High Very High Very High
Paracetamol 429 99.98 Very High Very High Very High
ischemia 12 99.68 Very High Very High Very High
headache 6 99.68 Very High Very High Very High
anesthesia 28 99.62 Very High Very High Very High
abdominal pain 5 99.16 Very High Very High Very High
withdrawal 3 99.16 Very High Very High Very High
Dysuria 1 98.70 Very High Very High Very High
Pain 22 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hepatotoxicity 290 99.90 Very High Very High Very High
Methemoglobinemia 2 99.90 Very High Very High Very High
Eosinophilia 2 99.90 Very High Very High Very High
Dizziness 1 99.90 Very High Very High Very High
Hematuria 2 99.88 Very High Very High Very High
Thrombosis Related Under Development 1 99.80 Very High Very High Very High
Cv Unclassified Under Development 15 99.68 Very High Very High Very High
Headache 6 99.68 Very High Very High Very High
Proteinuria 2 99.66 Very High Very High Very High
Vomiting 14 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GOT and GPT, normal at admission to the hospital, became markedly elevated and reached a maximum of 960 IU/I (GOT) and 993 IU/I (GPT) one day later, although the enzymes which indicate cholestasis remained at a normal level or did not increase.
Positive_regulation (elevated) of GPT associated with gallstones
1) Confidence 0.69 Published 1988 Journal Z Kardiol Section Abstract Doc Link 3149084 Disease Relevance 0.55 Pain Relevance 0.10
Increased serum glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) were noted in the 41.5 degrees C group 24 hr after exposure.
Positive_regulation (Increased) of GPT
2) Confidence 0.67 Published 1983 Journal Radiat. Res. Section Abstract Doc Link 6622647 Disease Relevance 0.24 Pain Relevance 0.10
Regardless of types of dietary fats, low protein aggravated acetaminophen-induced GOT and GPT levels.
Positive_regulation (induced) of GPT in fats associated with paracetamol
3) Confidence 0.63 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.55 Pain Relevance 0.44
Also, acetaminophen administration as well as high PUFA intake increase the activity of hepatic enzymes such as glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) and cause cell damage that increases the excretion of these enzymes into blood (Jaya et al., 1993).
Positive_regulation (increase) of glutamate-pyruvate transaminase in blood associated with glutamate and paracetamol
4) Confidence 0.63 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.75 Pain Relevance 0.27
Also, acetaminophen administration as well as high PUFA intake increase the activity of hepatic enzymes such as glutamate-pyruvate transaminase (GPT) and glutamate-oxaloacetate transaminase (GOT) and cause cell damage that increases the excretion of these enzymes into blood (Jaya et al., 1993).
Positive_regulation (increase) of GPT in blood associated with glutamate and paracetamol
5) Confidence 0.63 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788177 Disease Relevance 0.76 Pain Relevance 0.27
Further, this fraction, in the dose of 15 mg/100 g body wt for 90 days, did not show any increase in serum glutamate-pyruvate transaminase (SGPT) and blood urea, in normal control animals.
Positive_regulation (increase) of glutamate-pyruvate transaminase in blood associated with glutamate
6) Confidence 0.62 Published 2005 Journal Indian J. Exp. Biol. Section Abstract Doc Link 15991575 Disease Relevance 0.30 Pain Relevance 0.14
Paracetamol, alone, produces a slight increase of hepatic triglycerides while induces a significant (+ 108%) enhancement of S.GPT activity.
Positive_regulation (enhancement) of GPT associated with paracetamol
7) Confidence 0.59 Published 1980 Journal Boll. Soc. Ital. Biol. Sper. Section Abstract Doc Link 7470301 Disease Relevance 0.27 Pain Relevance 0.43
Ethanol administration to rats for 30 days and 90 days followed by paracetamol administration resulted in liver injury indicated by the significant increase in the serum GOT and GPT levels.
Positive_regulation (increase) of GPT in liver associated with paracetamol and injury
8) Confidence 0.57 Published 1993 Journal Indian J. Exp. Biol. Section Abstract Doc Link 8359854 Disease Relevance 0.26 Pain Relevance 0.42
A toxic dose of the drug ( LD20 ) produced elevated serum glutamate-pyruvate transaminase and lactate dehydrogenase activities 20-24 hr after drug administration only in 19- and 33-day-old animals.
Positive_regulation (elevated) of serum glutamate-pyruvate transaminase associated with glutamate
9) Confidence 0.56 Published 1984 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 6729816 Disease Relevance 0.17 Pain Relevance 0.52
However, changes in liver function as determined by elevation of serum glutamic-pyruvic transaminase was only observed at doses of 200 and 300 mg/kg.
Spec (determined) Positive_regulation (elevation) of serum glutamic-pyruvic transaminase in liver
10) Confidence 0.55 Published 1983 Journal Biochem. Pharmacol. Section Abstract Doc Link 6360177 Disease Relevance 0 Pain Relevance 0.09
It has been reported that when the liver is damaged with the introduction of infectious agents or chemicals, a significant increase in the levels of GOT and GPT were seen in the serum [38], and this increase has been attributed to damage to the structural integrity of the liver.
Positive_regulation (increase) of GPT in liver
11) Confidence 0.54 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2291455 Disease Relevance 0.59 Pain Relevance 0
Eosinophilia and elevation of serum GPT were noted in each 1 patient.
Positive_regulation (elevation) of serum GPT associated with eosinophilia
12) Confidence 0.49 Published 1982 Journal Jpn J Antibiot Section Abstract Doc Link 6980296 Disease Relevance 0.90 Pain Relevance 0.10
Much greater changes were found in the kidneys, with increased activity of glucose-6-phosphate dehydrogenase and decreased activities of aspartate and alanine aminotransferases, alkaline phosphatase, malic dehydrogenase, sorbitol dehydrogenase and gamma-glutamyltransferase, as well as a decreased phosphorylation to oxidation ratio in the mitochondria, indicating reduced adenosine triphosphate production.
Positive_regulation (activity) of alanine aminotransferase associated with adenocard
13) Confidence 0.49 Published 1994 Journal Eur J Clin Chem Clin Biochem Section Abstract Doc Link 7888481 Disease Relevance 0.13 Pain Relevance 0.10
Hepatocytolysis was determined by measuring the level of serum transaminases (GPT and GOT), steatosis by Sudan black staining, histological structures by hamatoxylineosin staining and the activity of enzymes such as SDH, GtDH, G-6-Pase and ATPase.
Positive_regulation (level) of GPT
14) Confidence 0.49 Published 1999 Journal Phytother Res Section Abstract Doc Link 10190184 Disease Relevance 0.08 Pain Relevance 0.17
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for 2 days) prevented (P < 0.001) the paracetamol (640 mg/kg)-induced rise in serum enzymes alkaline phosphatase (ALP) and transaminases (GOT and GPT), whereas the same dose of the extract was unable to prevent (P > 0.05) the CCI4-induced rise in serum enzyme levels. 4.
Positive_regulation (-induced) of GPT associated with paracetamol
15) Confidence 0.49 Published 1996 Journal Gen. Pharmacol. Section Abstract Doc Link 8909978 Disease Relevance 0.17 Pain Relevance 0.43
Pretreatment of rats with plant extract (500 mg/kg, orally twice daily for two days) prevented (P < 0.01) the acetaminophen (640 mg/kg) as well as CCl4 (1.5 ml/kg)-induced rise in serum transaminases (GOT and GPT). 4.
Positive_regulation (-induced) of GPT associated with paracetamol
16) Confidence 0.49 Published 1995 Journal Gen. Pharmacol. Section Abstract Doc Link 7590079 Disease Relevance 0.25 Pain Relevance 0.44
LDH and GPT release, on the other hand, was elevated at 2 and 5 g/L and calcium accumulation occurred at 5 g/L paracetamol only.
Positive_regulation (elevated) of GPT associated with paracetamol
17) Confidence 0.46 Published 1992 Journal Biochem. Pharmacol. Section Abstract Doc Link 1632830 Disease Relevance 0.53 Pain Relevance 0.97
Compared with the control group, liver tissue from the AAP group showed increased levels of caspase-3 activity and DNA fragmentation, decreased levels of GSH and increased serum GOT/GPT levels.
Positive_regulation (increased) of GPT in liver
18) Confidence 0.45 Published 2008 Journal Phytother Res Section Abstract Doc Link 18729249 Disease Relevance 0.42 Pain Relevance 0.07
On the other hand, dose-dependent elevations in serum enzyme glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) activities and hepatic triglyceride (TG) levels were observed following the administration of single doses of 0.5 and lg/kg acetaminophen.
Positive_regulation (elevations) of GPT associated with paracetamol
19) Confidence 0.45 Published 1976 Journal Toxicology Section Abstract Doc Link 941168 Disease Relevance 0.15 Pain Relevance 0.52
On the other hand, dose-dependent elevations in serum enzyme glutamic-oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT) and sorbitol dehydrogenase (SDH) activities and hepatic triglyceride (TG) levels were observed following the administration of single doses of 0.5 and lg/kg acetaminophen.
Positive_regulation (elevations) of glutamic-pyruvic transaminase associated with paracetamol
20) Confidence 0.45 Published 1976 Journal Toxicology Section Abstract Doc Link 941168 Disease Relevance 0.15 Pain Relevance 0.52

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