INT328621

Context Info Confidence 0.00 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.23

molecular_function (Il1rl1, Cfp) signal transduction (Il1rl1) extracellular space (Il1rl1) extracellular region (Il1rl1) plasma membrane (Il1rl1) intracellular (Il1rl1)

Il1rl1 (Rattus norvegicus) Cfp (Rattus norvegicus)

Pain Link Frequency Relevance Heat amygdala 55 89.24 narcan 30 85.00 opioid receptor 24 79.56 Opioid 13 50.00 nMDA receptor 9 5.00 antagonist 5 5.00 Central grey 3 5.00 nMDA receptor antagonist 3 5.00 projection neuron 2 5.00 isoflurane 2 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 33 63.76 Urological Neuroanatomy 4 50.00 Shock 6 5.00 Nociception 2 5.00 Phobia 1 5.00 Stupor 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results are very similar to previous data showing that FOS protein expression increases in the mPFC following extinction training (Santini et al., 2004), and recent results examining CREB activity in the mPFC following extinction training of different lengths (Mamiya et al., 2009).

Gene_expression (expression) of FOS protein Positive_regulation (increases) of mPFC

1) Confidence 0.00 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.06 Pain Relevance 0.23

General Comments

This test has worked.