INT328623

Context Info Confidence 0.05 First Reported 2010 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 0.50 Pain Relevance 1.17

lyase activity (NPL) carbohydrate metabolic process (NPL) cytoplasm (NPL)

Anatomy Link Frequency amygdala 2 NPL (Homo sapiens)

Pain Link Frequency Relevance Heat narcan 120 100.00 amygdala 220 97.56 opioid receptor 96 94.68 Opioid 52 50.00 antagonist 20 43.84 nMDA receptor 36 35.44 Central grey 12 5.00 nMDA receptor antagonist 12 5.00 projection neuron 8 5.00 isoflurane 8 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 132 100.00 Urological Neuroanatomy 16 50.00 Shock 24 5.00 Nociception 8 5.00 Phobia 4 5.00 Stupor 4 5.00

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Event

Anatomy

Negation

Speculation

Pain term

Disease term

The data clearly show that NAL has no effect on ERK phosphorylation driven by four exposures to the CS, strongly suggesting the amygdala and mPFC only come under the influence of the vlPAG when significant extinction learning occurs.

Phosphorylation (phosphorylation) of NAL in amygdala associated with narcan and amygdala

1) Confidence 0.05 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.08 Pain Relevance 0.29

This experiment allowed us to determine if the decrease in ERK phosphorylation in the amygdala and mPFC seen in the previous experiment following NAL infusion is specific to a procedure that results in the formation of extinction memory or if NAL decreases ERK phosphorylation related to retrieval or reconsolidation of memory.

Phosphorylation (phosphorylation) of NAL in amygdala associated with narcan and amygdala

2) Confidence 0.04 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.08 Pain Relevance 0.47

Because ERK activity is not simply related to one aspect of learning or memory, we tested the effect of NAL in the vlPAG on ERK phosphorylation driven by four presentations of the CS.

Phosphorylation (phosphorylation) of NAL associated with narcan

3) Confidence 0.04 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.16 Pain Relevance 0.28

The effects of NAL on fear extinction and the phosphorylation of ERK might reflect a disruption in reacting to changes in expectancy during learning (McNally and Cole, 2006).

Phosphorylation (phosphorylation) of NAL associated with anxiety disorder and narcan

4) Confidence 0.04 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.18 Pain Relevance 0.13

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