INT328625

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Context Info
Confidence 0.04
First Reported 2010
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.42
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (NPL, Ephb1) endosome (Ephb1) signal transduction (Ephb1)
lyase activity (NPL) plasma membrane (Ephb1) carbohydrate metabolic process (NPL)
Anatomy Link Frequency
amygdala 2
NPL (Homo sapiens)
Ephb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
narcan 90 100.00 Very High Very High Very High
amygdala 165 97.56 Very High Very High Very High
opioid receptor 72 94.68 High High
Opioid 39 50.00 Quite Low
antagonist 15 44.40 Quite Low
nMDA receptor 27 35.84 Quite Low
Central grey 9 5.00 Very Low Very Low Very Low
nMDA receptor antagonist 9 5.00 Very Low Very Low Very Low
projection neuron 6 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 99 100.00 Very High Very High Very High
Urological Neuroanatomy 12 50.00 Quite Low
Shock 18 5.00 Very Low Very Low Very Low
Nociception 6 5.00 Very Low Very Low Very Low
Phobia 3 5.00 Very Low Very Low Very Low
Stupor 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of NAL on fear extinction and the phosphorylation of ERK might reflect a disruption in reacting to changes in expectancy during learning (McNally and Cole, 2006).
NAL Regulation (effects) of Phosphorylation (phosphorylation) of ERK associated with anxiety disorder and narcan
1) Confidence 0.04 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.18 Pain Relevance 0.13
The data clearly show that NAL has no effect on ERK phosphorylation driven by four exposures to the CS, strongly suggesting the amygdala and mPFC only come under the influence of the vlPAG when significant extinction learning occurs.
NAL Neg (no) Regulation (effect) of Phosphorylation (phosphorylation) of ERK in amygdala associated with narcan and amygdala
2) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.08 Pain Relevance 0.29
Because ERK activity is not simply related to one aspect of learning or memory, we tested the effect of NAL in the vlPAG on ERK phosphorylation driven by four presentations of the CS.
NAL Regulation (effect) of Phosphorylation (phosphorylation) of ERK associated with narcan
3) Confidence 0.03 Published 2010 Journal Frontiers in Behavioral Neuroscience Section Body Doc Link PMC2927240 Disease Relevance 0.16 Pain Relevance 0.28

General Comments

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